Actively Recruiting
Liquid Phase Concentrated Growth Factor Versus Conventional Arthrocentesis in Temporomandibular Disc Displacement
Led by Horus University · Updated on 2026-03-11
32
Participants Needed
1
Research Sites
34 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to rigorously assess the effectiveness of LPCGF in the management of internal disc displacement in patients with TMD through a randomized clinical trial. By comparing LPCGF therapy with conventional arthrocentesis, this research looks to provide robust evidence on the efficacy, safety, and potential role of (LPCGF) as an alternative therapeutic choice for IDD.
CONDITIONS
Official Title
Liquid Phase Concentrated Growth Factor Versus Conventional Arthrocentesis in Temporomandibular Disc Displacement
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 45 years
- Patients classified as ASA I
- Complete or nearly complete natural teeth with Angle class I occlusion
- Diagnosed with unilateral disc displacement based on RDC/TMD criteria
- Symptoms include pain, joint sounds, or limited mouth opening (less than 40 mm)
- No prior surgical treatment for temporomandibular disorders
- Willingness to participate and follow the study protocol
You will not qualify if you...
- Temporomandibular joint pathology due to mechanical deformities
- Psychiatric or systemic diseases affecting healing (e.g., uncontrolled diabetes, autoimmune or connective tissue disorders, hematologic or neurologic conditions, rheumatological or previous infectious diseases, head and neck cancer)
- Unwillingness or contraindication to MRI
- Previous injections or surgeries on the temporomandibular joint
- Use of anticoagulants or anti-inflammatory drugs in the last 30 days
- Pregnant or breastfeeding women
- History of trauma or infection in the temporomandibular joint area
- Allergy to local anesthetics or study components
- Disc displacement with reduction without pain or limited mouth movement
AI-Screening
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Trial Site Locations
Total: 1 location
1
Faculty of Dentistry- Horus University in Egypt
Damietta, New Damietta, Egypt, 34518
Actively Recruiting
Research Team
M
Mohamed Ali Habib, Teaching assistant
CONTACT
E
Eman AbdElsalam Yousef, Associate professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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