Actively Recruiting
Injection of Liquid Phase Concentrated Growth Factor Versus Conventional Arthrocentesis in Management of Temporomandibular Disc Displacement: A Randomized Controlled Clinical Trial
Led by Horus University · Updated on 2026-03-11
32
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effectiveness of Liquid Phase Concentrated Growth Factor (LPCGF) compared to conventional arthrocentesis in treating internal disc displacement in patients with temporomandibular disorders (TMD). This randomized clinical trial aims to provide strong evidence on the safety, efficacy, and potential role of LPCGF as an alternative treatment for this condition. The study involves two groups: one group of 16 patients will receive injections of LPCGF, while another 16 patients will be treated with conventional arthrocentesis. Both groups include patients with anterior disc displacement with or without reduction. Treatments are delivered as procedures specifically targeting the temporomandibular joint. Participants will be assessed before treatment and then followed up at 1 week, 1 month, 3 months, and 6 months after intervention. Researchers will evaluate pain levels, mouth opening, joint sounds, mandibular movements, tenderness, and overall TMD symptoms through clinical assessments. This schedule helps monitor treatment effects, safety, and symptom changes during the study period.
CONDITIONS
Brief Title
Liquid Phase Concentrated Growth Factor Versus Conventional Arthrocentesis in Temporomandibular Disc Displacement
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18-45 years
- Patients scored as ASA I
- Presence of complete or nearly complete set of natural dentition with Angle class I occlusion
- Diagnosed with unilateral disc displacement according to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD)
- Symptoms include pain, joint sounds, or limited mandibular movement (maximum mouth opening less than 40mm)
- No prior surgical intervention for temporomandibular disorders
- Willingness to participate and follow study protocol
You will not qualify if you...
- Temporomandibular joint pathology related to mechanical deformities
- Psychiatric problems or systemic diseases affecting healing such as uncontrolled diabetes, autoimmune disorders, hematologic or neurologic disorders, inflammatory or connective tissue disorders, rheumatological or infectious diseases, head and neck cancer
- Unwillingness or contraindication to MRI
- Previous injections or surgical interventions of the temporomandibular joint
- Use of anticoagulants or anti-inflammatory medications within the last 30 days
- Pregnant or breastfeeding women
- History of trauma or infection in the temporomandibular joint region
- Allergy to local anesthetics or other study components
- Diagnosis of disc displacement with reduction without pain or limited mandibular movements
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single treatment intervention with assessments up to 6 months
Participants receive either an injection of liquid phase concentrated growth factor or conventional arthrocentesis to manage temporomandibular disc displacement.
1 baseline visit and 4 follow-up visits at 1 week, 1 month, 3 months, and 6 months after treatment
Trial Site Locations
Total: 1 location
1
Faculty of Dentistry- Horus University in Egypt
Damietta, New Damietta, Egypt, 34518
Actively Recruiting
Research Team
M
Mohamed Ali Habib, Teaching assistant
E
Eman AbdElsalam Yousef, Associate professor
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here