Actively Recruiting
LISA vs Endotracheal Surfactant in Preterm Neonates: A Lung Ultrasound Distribution Study
Led by Hamad General Hospital · Updated on 2026-04-07
22
Participants Needed
1
Research Sites
30 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This prospective, non-randomized, unblinded pilot study evaluates and compares the intrapulmonary distribution of exogenous surfactant in preterm neonates when administered via Less Invasive Surfactant Administration (LISA) versus conventional endotracheal intubation (ETT). Lung ultrasound (LUS) will be utilized to assess the pioneer Surfactant Distribution Homogeneity Index (SDHI) to quantify the evenness and extent of surfactant-induced lung aeration. Secondary objectives include evaluating changes in LUS scores, short-term clinical respiratory outcomes, and feasibility parameters for guiding future larger-scale trials.
CONDITIONS
Official Title
LISA vs Endotracheal Surfactant in Preterm Neonates: A Lung Ultrasound Distribution Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Gestational age between 24+0 and 42+6 weeks
- Clinical and radiographic diagnosis of Respiratory Distress Syndrome (RDS)
- Need for surfactant treatment within the first 3 days of life
- Written informed parental consent obtained
You will not qualify if you...
- Infants intubated at birth or who received prophylactic surfactant in the delivery room
- Major congenital anomalies or lung malformations such as congenital diaphragmatic hernia or pulmonary hypoplasia
- Syndromic or genetic conditions affecting lung or chest wall development
- Severe hemodynamic instability or congenital heart disease requiring intensive support
- Lack of parental consent for participation
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Women's Wellness and Research Center (WWRC), Hamad Medical Corporation
Doha, Qatar
Actively Recruiting
Research Team
L
Loay A Alkamel, MD, Mac
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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