Actively Recruiting
LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and Multiple Chronic Conditions
Led by Yale University · Updated on 2026-04-07
741
Participants Needed
10
Research Sites
211 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To establish the effectiveness and tolerability of standard of care anti-anginal treatment (beta-blocker and calcium channel blocker medications) in older adults with symptomatic Stable Ischemic Heart Disease (SIHD) and multiple chronic conditions (MCC).
CONDITIONS
Official Title
LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and Multiple Chronic Conditions
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 65 years or older
- Have two or more chronic conditions as defined by the Centers for Medicare and Medicaid Services
- Diagnosed with symptomatic Stable Ischemic Heart Disease with plans to start medical therapy, confirmed by positive non-invasive testing, coronary angiography with significant stenosis, or invasive physiologic testing
- Caregivers must be 18 years or older and identified as a caregiver of a LIVEBETTER participant
You will not qualify if you...
- Currently taking both a beta-blocker and a calcium channel blocker
- Contraindications to beta-blockers or calcium channel blockers such as significant low blood pressure, high grade AV block, severe symptomatic slow heart rate, or severe obstructive lung disease
- Documented intolerance to beta-blockers or calcium channel blockers
- High-risk coronary artery disease requiring immediate complete revascularization
- Plans for complete revascularization within 2 weeks
- Clear clinical need for beta-blockers or calcium channel blockers that prevents dose changes or switching
- Recent acute coronary syndrome with reduced ejection fraction or heart failure with reduced ejection fraction within the past year
- Participation in another clinical trial involving investigational treatments
- Primary language other than English or Spanish
- Unable to complete follow-up due to limited life expectancy or impaired decision-making
- Previously enrolled in LIVEBETTER
- Refused informed consent
- Caregivers who are professional paid caregivers
- Caregivers with primary language other than English or Spanish
- Caregivers unable to complete follow-up
- Caregivers previously enrolled in LIVEBETTER
- Caregivers who refused informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 10 locations
1
Yale School of Medicine
New Haven, Connecticut, United States, 06520
Actively Recruiting
2
Wellstar Research Institute
Marietta, Georgia, United States, 30060
Actively Recruiting
3
Cook County Health
Chicago, Illinois, United States, 60612
Actively Recruiting
4
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
5
Mt. Sinai Health System
New York, New York, United States, 10029
Actively Recruiting
6
NYC Health and Hospitals, Harlem Hospital
New York, New York, United States, 10037-1802
Not Yet Recruiting
7
Nirvana Integrative Medicine
New York, New York, United States, 10469
Actively Recruiting
8
Duke University, School of Medicine
Durham, North Carolina, United States, 27710
Actively Recruiting
9
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Not Yet Recruiting
10
Inova Health Care Services
Fairfax, Virginia, United States, 22033
Actively Recruiting
Research Team
M
Michael Nanna, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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