Actively Recruiting
The Liver Cirrhosis Cognitive Decline Scale (LiCCoS)
Led by University of Malaya · Updated on 2026-02-18
230
Participants Needed
1
Research Sites
50 weeks
Total Duration
On this page
Sponsors
U
University of Malaya
Lead Sponsor
M
Maharishi Markendeswar University (Deemed to be University)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to develop and test a new questionnaire called the Liver Cirrhosis Cognitive Decline Scale (LiCCoS) for adults with liver cirrhosis. This questionnaire is designed to help identify problems with thinking and daily mental functioning that are common in people with liver cirrhosis but are often missed during routine care. People with liver cirrhosis may experience problems such as forgetfulness, slowed thinking, trouble paying attention, or difficulty planning everyday tasks. These problems can affect daily life, safety, and treatment adherence. Existing cognitive tests often require special training or equipment and may not fully reflect how people experience these difficulties in daily life. This study aims to create a simple, patient-reported tool that captures these concerns in an easy and practical way. The main questions this study aims to answer are: 1. Can the LiCCoS questionnaire reliably measure cognitive difficulties in adults with liver cirrhosis? 2. Does the questionnaire correctly reflect differences in cognitive function across levels of liver disease severity? 3. Do LiCCoS scores relate to results from commonly used cognitive screening tests? Participants will be adults aged 18 to 75 years who have a confirmed diagnosis of liver cirrhosis and are attending outpatient clinics. Participation is voluntary. Participants will: Provide basic background information, such as age and medical history Complete the LiCCoS questionnaire about their thinking and daily mental functioning Complete standard cognitive screening tests commonly used in clinical care This study does not involve any treatment or change in medical care. The information collected will be used only for research purposes. The results are expected to help develop a reliable and easy-to-use tool that can support early recognition of cognitive difficulties in people with liver cirrhosis and improve communication between participants and health care providers.
CONDITIONS
Official Title
The Liver Cirrhosis Cognitive Decline Scale (LiCCoS)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-75 years
- Documented clinical diagnosis of liver cirrhosis based on imaging, histology, or validated clinical criteria
- Able to read and understand the language of the cognitive tests
- Willing and able to provide written informed consent
You will not qualify if you...
- Age under 18 or over 75 years
- Known overt hepatic encephalopathy Grade II or higher
- Use of central nervous system depressants, anticholinergics, or psychotropics started or changed within past 4 weeks
- Severe uncorrected visual or hearing impairment limiting ability to complete cognitive testing
- Any known neurological, psychological, substance use, or sleep disorders
- Severe systemic illness such as end-stage renal disease or decompensated heart failure that may impair cognition or participation
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Maharishi Markandeshwar (Deemed to be University)
Ambāla, Haryana, India, 133207
Actively Recruiting
Research Team
R
Rajat Rana, PhD
CONTACT
P
Plaban Nag, Pharm.D
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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