Clinical Course of acute-on-chronic liver failure syndrome and effects on prognosis.
Thierry Gustot, Javier Fernandez, Elisabet Garcia...
https://pubmed.ncbi.nlm.nih.gov/25877702Actively Recruiting
Age: 18Years - 80Years
All Genders
ID04613921
Liver Transplantation in Patients With Cirrhosis and Severe Acute-on-Chronic Liver Failure (ACLF): Indications and Outcomes
Led by European Foundation for Study of Chronic Liver Failure · Updated on 2025-10-20
3000
Participants Needed
106
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to compare 1-year survival rates of patients undergoing liver transplantation (LT) with different severities of liver failure, including those with acute-on-chronic liver failure (ACLF) grade 2 or 3 and those with decompensated cirrhosis without severe ACLF. It also assesses survival for patients with severe ACLF who are not listed for transplantation. The study explores factors influencing transplant decisions, outcomes on waiting lists, and post-transplant survival and quality of life. Participants are grouped into three categories: those listed for LT with ACLF-2 or 3 at listing or who develop these conditions while waiting; those listed with decompensated cirrhosis but without ACLF-2 or 3 and poor liver function (MELD score above 20); and those with ACLF-2 or 3 assessed for listing but ultimately not listed. The study follows all groups for one year after transplantation or inclusion to observe outcomes. Participants will be monitored for survival, transplant listing decisions, waiting list outcomes, graft acceptance characteristics, and quality of life after LT. Data collection includes clinical evaluations and tracking of patient and graft survival for one year. The study is observational, collecting information to improve understanding of transplantation outcomes and organ allocation for patients with severe liver disease.
CONDITIONS
Brief Title
Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs
Who Can Participate
Age: 18Years - 80Years
All Genders
Eligibility Criteria
You may qualify if you...
- Male or female aged 18 years or older
- Diagnosed with liver cirrhosis based on clinical, laboratory, endoscopic, ultrasonographic features, or histology
- Hospitalized for acute decompensation of liver cirrhosis and referred to the transplant team
- Patients listed for liver transplantation with ACLF-2 or 3 at listing or developing ACLF-2 or 3 while on the waiting list
- Patients listed for liver transplantation with decompensated cirrhosis without ACLF-2 or 3 and MELD score above 20 at listing
- Patients with ACLF-2 or 3 assessed for inclusion on the waiting list but not listed
- Provided informed consent or consent given by trusted person if unable to consent
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Monitoring
Duration - Up to 1 year after inclusion or liver transplantation
Participants who are listed for liver transplantation or assessed for inclusion are observed for their health status and outcomes.
Participants have regular visits as part of their clinical follow-up during the study period
Trial Site Locations
Total: 106 locations
1
Cedars-Sinai Comprehensive Transplant Center
Los Angeles, California, United States, 90048
Actively Recruiting
2
University of Colorado
Aurora, Colorado, United States, 80045
Actively Recruiting
3
Tampa General Hospital
Tampa, Florida, United States, 33606
Not Yet Recruiting
4
Piedmont Healthcare
Atlanta, Georgia, United States, 30309
Actively Recruiting
5
Northwestern Memorial Hospital
Chicago, Illinois, United States, 60611
Not Yet Recruiting
6
The University of Chicago Medicine
Chicago, Illinois, United States, 60637
Actively Recruiting
7
University of Maryland School of Medicine
Baltimore, Maryland, United States, 21201
Actively Recruiting
8
Weill Cornell Medicine
New York, New York, United States, 10021
Actively Recruiting
9
Icahn School of Medicine at Mount Sinai
New York, New York, United States, 10029-5674
Actively Recruiting
10
Montefiore Medical Center
New York, New York, United States, 10467
Not Yet Recruiting
11
University of Cincinnati
Cincinnati, Ohio, United States, 45219
Suspended
12
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Actively Recruiting
13
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Suspended
14
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Not Yet Recruiting
15
Baylor College of Medicine (Scott & White)
Dallas, Texas, United States, 75246
Not Yet Recruiting
16
Michael E DeBakey VA Medical Center
Houston, Texas, United States, 77030-4211
Not Yet Recruiting
17
Baylor St. Luke's Medical Centre
Houston, Texas, United States, 77030
Actively Recruiting
18
University of Utah Health
Salt Lake City, Utah, United States, 84132
Actively Recruiting
19
Austral University Hospital
Buenos Aires, Argentina
Actively Recruiting
20
Hospital Alemán
Buenos Aires, Argentina
Actively Recruiting
21
Italian Hospital in Buenos Aires
Buenos Aires, Argentina
Actively Recruiting
22
Austin Hospital
Heidelberg, Australia
Actively Recruiting
23
Sir Charles Gairdner Hospital
Nedlands, Australia
Suspended
24
Royal Prince Alfred Hospital
Sydney, Australia
Actively Recruiting
25
Medical University of Vienna, Department of Transplant Surgery
Vienna, Austria
Actively Recruiting
26
CUB Erasme Hospital
Brussels, Belgium
Actively Recruiting
27
Ghent University Hospital
Ghent, Belgium
Actively Recruiting
28
UZ Leuven
Leuven, Belgium
Actively Recruiting
29
Walter Cantídio University Hospital
Fortaleza, Brazil
Actively Recruiting
30
Irmandade Santa Casa de Misericórdia de Porto Alegre
Porto Alegre, Brazil
Actively Recruiting
31
Hospital das Clínicas da Universidade de São Paulo
São Paulo, Brazil
Actively Recruiting
32
University of Alberta
Edmonton, Canada
Actively Recruiting
33
University of Toronto, Multiorgan Transplant Program
Toronto, Canada
Actively Recruiting
34
Pablo Tobón Uribe Hospital
Medellín, Colombia
Actively Recruiting
35
Institute for Clinical and Experimental Medicine
Prague, Czechia
Not Yet Recruiting
36
APHP Beaujon
Clichy, France
Actively Recruiting
37
APHP Henri Mondor
Créteil, France
Actively Recruiting
38
Hôpital de la Croix-Rousse
Lyon, France
Actively Recruiting
39
CHU Montpellier-Hôpital Saint Eloi
Montpellier, France
Actively Recruiting
40
APHP Hôpitaux Universitaires Pitié Salpêtrière
Paris, France
Actively Recruiting
41
CHU Rennes, Hôpital De Pontchaillou
Rennes, France
Actively Recruiting
42
Hautepièrre Hospital, Service de Réanimation Médicale
Strasbourg, France
Actively Recruiting
43
Trousseau Hospital,
Tours, France
Actively Recruiting
44
Hôpital Paul Brousse
Villejuif, France
Actively Recruiting
45
University Hospital Regensburg
Regensburg, Eastern Bavaria, Germany
Not Yet Recruiting
46
Universitätsklinikum Schleswig-Holstein (UKSH)
Kiel, Schleswig-Holstein, Germany
Not Yet Recruiting
47
University Hospital Aachen
Aachen, Germany
Suspended
48
Charité University Hospital
Berlin, Germany
Actively Recruiting
49
Goethe University Clinic
Frankfurt, Germany
Not Yet Recruiting
50
University Medical Center, Hamburg Eppendorf
Hamburg, Germany
Actively Recruiting
51
Hannover Medical School
Hanover, Germany
Not Yet Recruiting
52
University Hospital Heidelberg
Heidelberg, Germany
Not Yet Recruiting
53
Jena University Hospital
Jena, Germany
Suspended
54
Universitätsklinikum Schleswig-Holstein (UKSH)
Kiel, Germany
Actively Recruiting
55
Leipzig University Hospital
Leipzig, Germany
Not Yet Recruiting
56
University Hospital Mainz
Mainz, Germany
Suspended
57
LMU Großhadern
Munich, Germany
Suspended
58
UKM Muenster
Münster, Germany
Actively Recruiting
59
University Hospital Tübingen
Tübingen, Germany
Actively Recruiting
60
Queen Mary Hospital, The University of Hong Kong
Hong Kong, Hong Kong
Suspended
61
Aster CMI Hospital
Bengaluru, Karnataka, India
Not Yet Recruiting
62
Kasturba Hospital
Mumbai, Maharashtra, India
Not Yet Recruiting
63
Seth GSMC & KEM Hospital
Mumbai, Maharashtra, India
Not Yet Recruiting
64
Indraprastha Apollo Hospitals
New Delhi, National Capital Territory of Delhi, India
Not Yet Recruiting
65
Mahatma Gandhi University of Medical Sciences and Technology
Jaipur, Rajasthan, India
Not Yet Recruiting
66
Dr.Rela Institute & Medical Centre
Chennai, India
Actively Recruiting
67
Fortis Hospital Noida, FEHI, FMRI
Gurugramam, India
Not Yet Recruiting
68
Medanta Medicity
Gurugramam, India
Not Yet Recruiting
69
Amrita Institute of Medical Sciences
Kochi, India
Actively Recruiting
70
Global Hospital. Super speciality & transplant centre
Mumbai, India
Not Yet Recruiting
71
Max Saket Hospital
New Delhi, India
Active, Not Recruiting
72
Yashoda Hospitals
Secunderabad, India
Not Yet Recruiting
73
Ospedale Papa Giovanni XXIII-
Bergamo, Italy
Not Yet Recruiting
74
S.Orsola Hospital - Alma Mater Studiorum University of Bologna
Bologna, Italy
Actively Recruiting
75
Ca' Granda. Policlinico Milano
Milan, Italy
Actively Recruiting
76
Niguarda Hospital
Milan, Italy
Actively Recruiting
77
University and Hospital of Padova
Padova, Italy
Actively Recruiting
78
Kyushu University Hospital
Fukuoka, Japan
Actively Recruiting
79
Hiroshima University Hospital
Hiroshima, Japan
Actively Recruiting
80
Kyoto University Hospital
Kyoto, Japan
Actively Recruiting
81
Nagasaki University Hospital
Nagasaki, Japan
Actively Recruiting
82
Tokyo University Hospital
Tokyo, Japan
Actively Recruiting
83
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Mexico City, Mexico
Actively Recruiting
84
University Medical Center Groningen (UMCG)
Groningen, Netherlands
Not Yet Recruiting
85
Erasmus MC University Medical Center
Rotterdam, Netherlands
Actively Recruiting
86
Auckland City Hospital- New Zealand Liver Transplant Unit
Auckland, New Zealand
Suspended
87
Medical University of Warsaw, Dept. of General, Transplant & Liver Surgery
Warsaw, Poland
Actively Recruiting
88
Hospital Curry Cabral
Lisbon, Portugal
Actively Recruiting
89
Samsung Medical Center
Seoul, South Korea
Not Yet Recruiting
90
Hospital Clinic in Barcelona
Barcelona, Spain
Actively Recruiting
91
Hospital Vall d'Hebron
Barcelona, Spain
Actively Recruiting
92
Hospital Universitario 12 de Octubre
Madrid, Spain
Actively Recruiting
93
Hospital Universitario Ramón y Cajal
Madrid, Spain
Actively Recruiting
94
Hospital Marqués de Valdecilla
Santander, Spain
Actively Recruiting
95
Hospital Universitario Virgen del Rocío
Seville, Spain
Actively Recruiting
96
Hospital Universitari i Politècnic La Fe
Valencia, Spain
Actively Recruiting
97
Karolinska Institutet
Stockholm, Stockholm County, Sweden, 171 77
Actively Recruiting
98
Geneva University Hospital (HUG)
Geneva, Switzerland
Not Yet Recruiting
99
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, Taiwan
Actively Recruiting
100
Inonu University, Liver Transplantation Institute
Malatya, Anatolia, Turkey (Türkiye)
Actively Recruiting
101
Istanbul Memorial Bahcelievler Hospital
Istanbul, Turkey (Türkiye)
Suspended
102
Queen Elizabeth Hospital Birmingham
Birmingham, United Kingdom
Actively Recruiting
103
Scottish Liver Transplant Unit, Royal Infirmary
Edinburgh, United Kingdom
Actively Recruiting
104
Leeds Teaching Hospitals NHS Trust
Leeds, United Kingdom
Actively Recruiting
105
King's College Hospital
London, United Kingdom
Actively Recruiting
106
Royal Free Hospital
London, United Kingdom
Actively Recruiting
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Research Team
A
Anna Bosch
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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Liver transplantation in the most severely ill cirrhotic patients: A multicenter study in acute-on-chronic liver failure grade 3.
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https://pubmed.ncbi.nlm.nih.gov/28645736Factors Associated with Survival of Patients With Severe Acute-On-Chronic Liver Failure Before and After Liver Transplantation.
Vinay Sundaram, Rajiv Jalan, Tiffany Wu...
https://pubmed.ncbi.nlm.nih.gov/30576643