Actively Recruiting
Liver Volume Variation Effect on SBRT Planning and Delivery for Upper Abdominal Malignancies
Led by University of Pittsburgh · Updated on 2025-08-07
17
Participants Needed
1
Research Sites
97 weeks
Total Duration
On this page
Sponsors
U
University of Pittsburgh
Lead Sponsor
A
American College of Radiation Oncology
Collaborating Sponsor
AI-Summary
What this Trial Is About
Standard planning constraints for liver SBRT incorporate strict dose-volume limits for normal liver parenchyma to minimize the risk of radiation-induced liver disease. The presence of diurnal and fasting/fed variations in liver volume therefore carry substantial potential for introducing errors into estimates of dose-volume distribution within normal liver tissue, as well as affecting day-to-day setup fidelity and organ alignment for treatment. This prospective study will examine how diurnal and fast-fed variations in liver volume affect treatment planning for abdominal SBRT.
CONDITIONS
Official Title
Liver Volume Variation Effect on SBRT Planning and Delivery for Upper Abdominal Malignancies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have primary upper abdominal (pancreatic, bile duct, liver) cancer or upper abdominal metastases (liver, adrenal, upper abdominal lymph nodes) planned to undergo SBRT.
You will not qualify if you...
- Had prior Radiation Therapy to the liver
- Contraindication to receipt of iodinated IV contrast for CT (such as renal insufficiency or allergy that cannot be overcome by premedication)
- Pregnancy/lactation OR woman of childbearing potential who is unable or unwilling to use adequate contraception during Radiation Therapy.
- Inability to fast.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, United States, 15232
Actively Recruiting
Research Team
S
Samantha Demko, BSN
CONTACT
B
Brieanna Marino, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here