Actively Recruiting
Liver X Receptor (LXR) as a Novel Therapeutic Target in Diabetic Retinopathy (DR)
Led by University of Alabama at Birmingham · Updated on 2025-09-17
104
Participants Needed
1
Research Sites
468 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Results from large clinical trials demonstrate a strong association between lipid abnormalities and progression of the most common microvascular complication, diabetic retinopathy (DR). We found that activation of a master regulator of cholesterol metabolism, the nuclear hormone receptors liver X receptors (LXRα/LXRβ), prevents DR in rodent models. In this application, we seek to understand the mechanisms responsible for the beneficial effects of LXR agonists on retina and on bone marrow (BM) to preserve the function of reparative cells while reducing inflammatory cell.
CONDITIONS
Official Title
Liver X Receptor (LXR) as a Novel Therapeutic Target in Diabetic Retinopathy (DR)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men or women between 21 and 98 years old
- Must have a diagnosis of diabetes or be a healthy aged control
- Must be willing and able to cooperate with the study procedures
You will not qualify if you...
- Active acute or chronic infections such as HIV, Hepatitis B or C, or tuberculosis
- Current malignancy
- History of stroke or cerebral vascular procedures
- Pregnant women
- History of organ transplantation or presence of a graft
- Severe kidney disease with estimated glomerular filtration rate less than 20 cc/min or low albumin levels below 3.6
- Unwillingness to abstain from alcohol
- Anemia
- Presence of age-related macular degeneration, glaucoma, uveitis, hereditary degenerations, or other significant eye diseases besides diabetic retinopathy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294
Actively Recruiting
Research Team
J
Jennifer Moorer
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
6
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