Actively Recruiting
LiverPAL: A Trial of Inpatient Palliative Care for Patients With Advanced Liver Disease
Led by Massachusetts General Hospital · Updated on 2025-07-17
200
Participants Needed
1
Research Sites
197 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to evaluate whether early integration of palliative care in the care of hospitalized patients with advanced liver disease (AdvLD) can improve patients' quality of life, physical symptoms, mood, and serious illness communication. Palliative care is a medical specialty focused on lessening (or "palliating") symptoms and assisting in coping with serious illness.
CONDITIONS
Official Title
LiverPAL: A Trial of Inpatient Palliative Care for Patients With Advanced Liver Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Hospitalized patient with advanced liver disease, such as cirrhosis, with one or more of the following in the last 6 months: ascites requiring diuretics or large volume paracenteses, spontaneous bacterial peritonitis, hepatic hydrothorax requiring diuretics, variceal bleeding, or overt hepatic encephalopathy requiring medications
- Ability to understand English
- Adult caregiver (18 years or older) who is a relative or friend the patient relies on and is likely to be present during hospital or clinic visits or willing to participate by phone
- Caregiver able to understand English and complete questionnaires
You will not qualify if you...
- Prior liver transplantation
- Uncontrolled hepatic encephalopathy, cognitive impairment, psychiatric disorder, or other condition that prevents giving informed consent
- History of extrahepatic cancer treated with curative intent within 5 years (except non-melanoma skin cancer)
- Hepatocellular carcinoma beyond Milan criteria
- Currently receiving hospice care
- Score below 10 on the Simplified Animal Naming Test
- Caregiver unable to understand English
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
Research Team
G
Grace Bizup, BA
CONTACT
W
William Munroe, BA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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