Actively Recruiting
Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone
Led by St. Louis University · Updated on 2026-04-22
120
Participants Needed
16
Research Sites
504 weeks
Total Duration
On this page
Sponsors
S
St. Louis University
Lead Sponsor
O
Orthopedic Research and Education Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of the clinical study is to investigate whether the local delivery of bisphosphonate as a surgical adjuvant can decrease the chance of a giant cell tumor of bone coming back to the same location. The hypothesis is that the local administration of bisphosphonate will decrease the rate of the tumor returning compared to traditional aggressive surgical removal of the tumor.
CONDITIONS
Official Title
Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Primary benign giant cell tumor of bone
- Tumor located in an extremity (arm or leg)
- Tumor can be treated with intralesional curettage preserving at least one intact bone column
- No prior systemic bisphosphonate or denosumab therapy
You will not qualify if you...
- Recurrent giant cell tumor of bone
- Tumor located outside of extremities
- Tumor too large or invasive for intralesional surgery due to bone loss, joint invasion, or large soft tissue involvement
- Children and pregnant individuals
- Previous systemic bisphosphonate or denosumab therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 16 locations
1
University of California - Los Angeles
Los Angeles, California, United States, 90404
Actively Recruiting
2
Indiana University
Indianapolis, Indiana, United States, 46202
Actively Recruiting
3
University of Iowa
Iowa City, Iowa, United States, 52242
Actively Recruiting
4
University of Kansas
Overland Park, Kansas, United States, 66211
Completed
5
Johns Hopkins University Hospital
Baltimore, Maryland, United States, 21287
Actively Recruiting
6
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
7
Boston Children's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
8
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
Actively Recruiting
9
Saint Louis University
St Louis, Missouri, United States, 63110
Actively Recruiting
10
Wake Forest University
Winston-Salem, North Carolina, United States, 27157
Completed
11
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Actively Recruiting
12
University of Oklahoma
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
13
Allegheny-Singer Research Institute
Pittsburgh, Pennsylvania, United States, 15212
Actively Recruiting
14
University of Washington
Seattle, Washington, United States, 98195
Completed
15
McGill University Health Centre
Montreal, Quebec, Canada, H3G 1A4
Completed
16
All India Institute of Medical Science
New Delhi, India, 110029
Actively Recruiting
Research Team
A
Allison Gruender, RN
CONTACT
M
Marsha Steffen, RN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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