Effect of Crushed Vitamin K2 Capsules on Bone Healing After Tooth Extraction Randomized Trial in Adults Needing Mandibular Single-Rooted Tooth Extraction

What this Trial Is About

Researchers are evaluating the effects of socket grafting with crushed vitamin K2 menaquinone capsules compared to no grafting on bone density and socket dimensions after tooth extraction. This randomized controlled trial focuses on patients needing extraction of mandibular single-rooted teeth. The study aims to understand how vitamin K2 influences bone remodeling and preservation in the extraction socket. Participants are divided into two groups the study group receives socket grafting with crushed vitamin K2 capsules covered by an absorbent sponge and stabilized with non-resorbable sutures, while the control group undergoes extraction without grafting but with the socket covered and sutured similarly. Bone density and socket dimensions are measured immediately after extraction and again after 4 months using cone beam computed tomography CBCT. Core biopsies are also taken at implant placement to analyze new bone formation. During the study, patients will undergo tooth extraction under local anesthesia, with careful cleaning of the socket before treatment. Follow-up assessments include CBCT scans to evaluate bone changes and biopsies at implant placement for detailed bone analysis. The main outcome is marginal bone loss assessed at baseline and after 4 months, with additional measures of implant stability and new bone formation. The total participation duration spans from extraction through the 4-month follow-up and implant placement.

The Local Effect of Vitamin K2 on Bone Remodeling in Socket Preservation