Actively Recruiting
Local 5-Fluorouracil Injection for the Treatment of Chalazia: A Prospective, Comparative Study
Led by University of Washington · Updated on 2020-02-06
120
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effectiveness of different treatments for chalazia, which are lumps that form on the eyelid. This study compares four common treatments: incision and curettage (a minor surgical procedure), local injection of triamcinolone (a steroid), local injection of 5-fluorouracil (a drug), and a combination injection of triamcinolone and 5-fluorouracil. The goal is to find out which treatment works best for reducing the size of chalazia after four weeks. Participants will be randomly assigned to one of the four treatment groups. Treatments include making a small incision to remove the chalazion, injecting triamcinolone, injecting 5-fluorouracil, or injecting a mixture of both drugs directly into the chalazion. If the chalazion remains at follow-up visits, additional injections or treatments may be given according to the group assigned. During the study, participants will have follow-up visits to monitor the size of their chalazion and assess treatment effects. Researchers will measure the chalazion size at four weeks to compare outcomes between groups. The study involves clinical examinations and possible repeated treatments if needed. Participation lasts through the treatment and follow-up period, with safety and effectiveness closely observed.
CONDITIONS
Brief Title
Local 5-Fluorouracil Injection for the Treatment of Chalazia: A Prospective, Comparative Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Single or multiple chalazia in a single eyelid
- Adults aged 18 years and older
You will not qualify if you...
- Chalazia present for less than one month
- No previous injection or incision and curettage treatment for chalazia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 4 weeks
Participants receive one of four treatments for chalazia: incision and curettage, local injection of triamcinolone, local injection of 5-fluorouracil, or local injection of a triamcinolone/5-fluorouracil mixture. If the chalazion persists at follow-up, additional injections may be given based on the assigned treatment.
1 treatment visit and 1 follow-up visit
Trial Site Locations
Total: 1 location
1
University of Washington Eye Institute at Harborview
Seattle, Washington, United States, 98104
Actively Recruiting
Research Team
S
Simona Vuletic
I
Ian Luttrell
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
4
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