Actively Recruiting
Local Radiofrequency Ablation Plus External Beam Radiation for the Treatment of Painful Thoracic and Lumbar Spine Tumors
Led by UNC Lineberger Comprehensive Cancer Center · Updated on 2026-04-23
70
Participants Needed
1
Research Sites
258 weeks
Total Duration
On this page
Sponsors
U
UNC Lineberger Comprehensive Cancer Center
Lead Sponsor
M
Medtronic
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study looks at how well a combination of treatments helps reduce pain in people with tumors in the middle and lower back (thoracic and lumbar spine). All participants receive the same treatment, which includes a procedure to stabilize the spine (kyphoplasty), radiofrequency ablation will be with the Osteocool system and radiation therapy. The goal is to see how effective this combined approach is at relieving pain. The purpose of this study is to find out whether combining these three treatments provides better pain relief for patients with thoracic and lumbar spine tumors. This study is for adults who have cancer that has spread to the thoracic or lumbar spine and who report moderate to severe back pain (a pain score of 5 or higher on a 0-10 pain scale).
CONDITIONS
Official Title
Local Radiofrequency Ablation Plus External Beam Radiation for the Treatment of Painful Thoracic and Lumbar Spine Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent and HIPAA authorization provided
- Able and willing to follow study procedures
- Age 18 years or older at consent
- Life expectancy longer than 1 month and suitable for treatment
- Metastatic tumor in thoracic or lumbar spine, with lytic or mixed lytic/blastic tumor type
- Back pain score of 5 or higher on a visual analog scale
You will not qualify if you...
- Active infection needing systemic therapy
- Pregnant or breastfeeding
- Currently taking Avastin or blood thinners that cannot be stopped
- Enrolled in another cancer clinical trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UNC Hospitals
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
Research Team
M
Markeela Lipscomb
CONTACT
D
Desma Jones
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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