Actively Recruiting
Local Subcutaneous Gentamicin for Prevention of Surgical Site Infection After Elective Cesarean Section
Led by Western Galilee Hospital-Nahariya · Updated on 2025-12-31
100
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to evaluate whether local subcutaneous administration of gentamicin reduces the incidence of surgical site infection (SSI) following elective cesarean section. The study will also assess the safety of local gentamicin administration. The main questions this study aims to answer are: * Does local subcutaneous administration of gentamicin reduce the rate of superficial and deep surgical site infections within 30 days after elective cesarean delivery? * Are there differences between groups in postoperative complications, including wound healing, fever, need for additional antibiotic treatment, or hospital readmission? Researchers will compare women who receive local subcutaneous gentamicin at the surgical site in addition to standard antibiotic prophylaxis to women who receive standard antibiotic prophylaxis alone. Participants will: * Undergo an elective cesarean section according to standard clinical practice * Receive either local subcutaneous gentamicin administration or no local antibiotic administration, in addition to standard systemic antibiotic prophylaxis * Be followed clinically for signs of surgical site infection and other postoperative complications during hospitalization and at follow-up visits up to 30 days after surgery
CONDITIONS
Official Title
Local Subcutaneous Gentamicin for Prevention of Surgical Site Infection After Elective Cesarean Section
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 18 years and older
- Undergoing elective cesarean section
- Gestational age of 24 weeks or more
- Planned postoperative follow-up of 30 days
- Eligible for standard antibiotic prophylaxis according to institutional protocol
- Able to provide informed consent
You will not qualify if you...
- Known allergy or hypersensitivity to aminoglycosides
- Known allergy or hypersensitivity to systemic antibiotic prophylaxis agents
- Current or planned use of immunomodulatory or immunosuppressive therapy
- Requirement for therapeutic (non-prophylactic) antibiotic treatment at the time of surgery
- Active infection or clinical condition requiring antibiotic treatment
- Inability or unwillingness to comply with study procedures or follow-up
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Western Galilee Hospital-Nahariya
Nahariya, Israel
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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