Actively Recruiting
Locally AblatiVe TherApy in OLigO-pRogressive SOlid TUmorS (VALOROUS)
Led by University of California, Davis · Updated on 2024-12-17
250
Participants Needed
1
Research Sites
378 weeks
Total Duration
On this page
Sponsors
U
University of California, Davis
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a phase 2 pragmatic study that evaluates the clinical benefit of continuing systemic therapy with the addition of locally ablative therapies for oligo-progressive solid tumors as the primary objective. The primary outcome measure is the time to treatment failure (defined as time to change in systemic failure or permanent discontinuation of therapy) following locally ablative therapy.
CONDITIONS
Official Title
Locally AblatiVe TherApy in OLigO-pRogressive SOlid TUmorS (VALOROUS)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Must have one of the following confirmed cancers: breast malignancy, gynecological malignancy, head and neck malignancy, sarcomas, or other solid malignancy specified in the protocol
- Provide signed and dated informed consent
- Willing to comply with all study procedures and available for the study duration
- Age 18 years or older at time of consent
- Currently on systemic therapy and eligible to continue current treatment with no more than a 30-day planned break for local ablative therapy
- Have received at least one line of systemic therapy for metastatic disease with at least 3 months of clinical benefit on the most recent therapy before new metastatic lesions
- Have 5 or fewer progressing or new metastatic lesions
- All progressing or new metastatic lesions can be safely treated with local ablative therapies as determined by treating specialists
You will not qualify if you...
- Medical conditions that prevent use of locally ablative therapies
- History of treatment-related toxicities that limit or prevent locally ablative therapies
- Progressing intracranial lesions
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of California, Davis
Sacramento, California, United States, 95817
Actively Recruiting
Research Team
S
Selina Laqui
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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