Actively Recruiting
Locally Advanced NSCLC Treated With Radiochemotherapy: Phase 2 Study on the Value of a Stereotactic Boost
Led by Centre Antoine Lacassagne · Updated on 2026-01-05
42
Participants Needed
1
Research Sites
451 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a monocentric, non-randomized, open-label, superiority phase II clinical investigation evaluating the efficacy of additional Cyberknife irradiation after a doublet of Platinum Salts-based chemotherapy and concomitant radiotherapy in patients with locally advanced non-small cell lung carcinoma (NSCLC), with an interim analysis.
CONDITIONS
Official Title
Locally Advanced NSCLC Treated With Radiochemotherapy: Phase 2 Study on the Value of a Stereotactic Boost
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 years old or more
- ECOG performance status from 0 to 2
- Histologically confirmed non-small cell lung cancer
- Stage III non-metastatic tumor not suitable for immediate surgery
- 1 to 3 target tumor volumes less than 5 cm on chest CT after conventional radiotherapy (34 to 46 Gy)
- Completion of 2 cycles of platinum-based induction chemotherapy and at least 40 Gy radiotherapy with at least 2 cycles of concurrent platinum-based chemotherapy
- No contraindication to implantable venous devices
- Signed informed consent after reading patient information
- Negative pregnancy test if applicable
- Eligible for National Health Insurance in France
- Chest CT scan performed prior to Taxcis chemotherapy
You will not qualify if you...
- Positive EGFR mutation
- Exercise-induced dyspnea with heart failure stage III or higher (NYHA classification)
- Coronary syndrome or heart failure in the last three months
- Pulmonary function test showing FEV1 less than 1 liter contraindicating radiotherapy
- Toxicity after radiochemotherapy that contraindicates Cyberknife irradiation
- Vulnerable populations defined by EU regulations, including incapacitated persons without consent, pregnant or breastfeeding women not covered by provisions, and adults under legal protection or unable to consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Centre Antoine Lacassagne
Nice, France, 06000
Actively Recruiting
Research Team
S
Study coordinator
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here