Malle

Researchers are evaluating the safety and performance of the ORIGIN4 CR cruciate retaining devices used in total knee replacement surgery. This observational study aims to measure the safety by tracking the proportion of patients needing revision surgery one year after the procedure and to assess performance using the Knee Society Score KSS both for the knee and function at one year. The hypothesis is that patients will notice a significant natural feel improvement in the prosthesis within the first year, with slight further gains at two years, along with better overall satisfaction. The study will include 199 patients who will receive treatment with the ORIGIN4 CR devices and associated instruments. Patients will be enrolled over an 18-month period and followed for 24 months. This single-arm study does not include a comparison group and will monitor patients up to two years after their surgery to assess outcomes. Participants will be asked to attend follow-up visits at one and two years after their surgery. During these visits, researchers will evaluate safety through revision rates and assess performance using the Knee Society Score and Function Score, patient satisfaction surveys, and the Forgotten Joint Score questionnaire. The study focuses on understanding quality of life and prosthesis function after total knee replacement with the ORIGIN4 CR device.

Researchers are collecting detailed data about suicide attempts and suicidal thoughts among people who come to healthcare services in Flanders. The study aims to understand how often these behaviors occur, the methods used, and how many receive proper follow-up care after a suicide attempt. This observational study uses a structured interview tool called the Guideline for Suicide Care and Evaluation LOES to gather comprehensive information. Participants undergo a two-part semi-structured interview administered by trained nurses, psychologists, or psychiatrists. The first part happens soon after admission to a healthcare facility and collects information on emotional state, mental health history, social support, hopelessness, and suicidal behavior. The second part provides a deeper evaluation of risk factors, treatment needs, motivations, planning, and coping strategies related to suicidality. Throughout the study, participants provide demographic, clinical, and psychological information through interviews. Researchers assess suicidal intent, planning, past behavior, substance use risk, and care needs. The study tracks treatment agreements and care pathways after assessment. Data collection occurs at the initial presentation, with no drug or medical treatment being tested. The total participation time varies depending on the individuals healthcare encounters and follow-up.