Cochabamba

Researchers are conducting an international, multicenter observational study to understand acute kidney injury requiring renal replacement therapy (AKI-RRT) in Latin American countries. The study focuses on the epidemiology, patient outcomes, and care processes for those with AKI-RRT. It also aims to identify how these factors vary across different Latin American countries and what demographic, clinical, and socioeconomic elements affect patient outcomes. The study collects a wide range of data including clinical details, laboratory results, treatments, care processes, and patient outcomes to create a comprehensive database. It includes adult patients admitted to intensive care units diagnosed with stage 3 acute kidney injury who begin renal replacement therapy within a specific timeframe relative to ICU admission. The study does not involve experimental treatments but observes current care practices across multiple sites. Participants are monitored from enrollment through hospital discharge or up to 90 days to track in-hospital mortality and other outcomes. The research helps compare care approaches and results between countries and supports further clinical research in AKI-RRT. The total participation duration depends on the patient's hospital stay or 90 days, whichever comes first.

Gallstones are common in women and are a major risk factor for gallbladder cancer (GBC), a serious disease with limited treatment options. This research aims to improve how well we can predict the risk of GBC and detect it early by studying differences in geography, environment, lifestyle, ethnicity, gender, and molecular markers. The goal is to develop better prevention programs and improve understanding of how lifestyle and genetic factors contribute to GBC development. The study involves collecting epidemiological, clinical, and dietary information, along with samples of blood, saliva, urine, bile, feces, and gallbladder tissue. These samples will be used to identify and study new biomarkers for GBC, build a biorepository, develop a risk scoring system, and explore new treatment options. The study includes patients with gallbladder cancer or precancerous conditions and those with gallstones scheduled for gallbladder removal. Participants will provide various samples and data which researchers will use to measure the number of participants developing gallbladder cancer or dysplasia, either at the start or after examination of removed gallbladders. The project also supports training researchers and aims to help shape health policies. The study is observational and does not involve any experimental treatments, focusing instead on gathering data to improve prevention, diagnosis, and future treatments for GBC.