Divinopolis

Researchers are evaluating two different consolidation chemotherapy regimens following neoadjuvant chemoradiation therapy (nCRT) in patients with distal rectal cancer. This study aims to compare fluoropyrimidine-alone chemotherapy with fluoropyrimidine plus oxaliplatin chemotherapy to determine their effects on primary tumor response and the possibility of organ preservation through a Watch and Wait (WW) approach. The trial is a multi-center, prospective randomized controlled study focused on patients with magnetic resonance (MR)-defined distal rectal tumors classified as mrT2-3N0-1 and located no more than 1 cm above the anorectal ring.