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Study of Trastuzumab Deruxtecan with Pembrolizumab versus Platinum-based Chemotherapy with Pembrolizumab as First-line Treatment in Locally Advanced or Metastatic HER2 Overexpressing Non-squamous Non-small Cell Lung Cancer

This clinical trial is designed to assess the efficacy and safety of trastuzumab deruxtecan (T-DXd; Enhertu®) in combination with pembrolizumab versus platinum-based chemotherapy in combination with pembrolizumab in participants with no prior therapy for locally advanced unresectable or metastatic non-squamous NSCLC, whose tumors have HER2-overexpressing and PD-L1 TPS \<50% without known AGA that have locally available therapies targeting their AGAs in first-line advanced/metastatic setting.

Age: 18Years +All GendersPhase 3
100 locations
Votorantim Clinical Trials | DecenTrialz