Baldwin

Researchers are comparing two surgical methods for patients with chronic rhinosinusitis with nasal polyps CRSwNP that do not respond to usual treatments. This study focuses on evaluating the safety and effectiveness of reboot surgery, which removes all inflamed sinus mucosa, against conventional full house functional endoscopic sinus surgery FESS. The goal is to see which approach reduces polyp recurrence, improves quality of life, decreases steroid use, and lowers complications over 24 months. Participants will be randomly assigned to one of two groups one undergoing reboot surgery involving complete removal of inflamed mucosa down to the bone, and the other receiving conventional FESS where healthy mucosa is preserved. This study will track outcomes including recurrence rates, symptom-free periods, quality of life improvements measured by SNOT-22 scores, and complication rates such as bleeding or infection. Throughout the study, participants will have regular evaluations including endoscopic examinations to check for polyp recurrence. Researchers will monitor quality of life, steroid use, and complications over a 24-month period following surgery. The study aims to provide a detailed comparison of the two surgical techniques for managing refractory CRSwNP and will be conducted by Kafrelsheikh University starting in January 2026.