Brandon

Researchers are evaluating the use of intravenous thrombolysis IVT with tenecteplase for patients who have suffered an acute ischemic stroke AIS. This study aims to compare the effectiveness of standard-dose tenecteplase 0.25 mgkg body weight against a lower dose 0.18 mgkg and also to assess scenarios where no tenecteplase is given upfront, particularly in patients recently taking direct oral anticoagulants DOACs or those planned for emergency endovascular thrombectomy EVT. The trial seeks to provide clearer guidance on dosing and treatment choices, especially for specific patient groups like the elderly or those with other health conditions. Participants are randomly assigned to one of three groups receiving standard-dose tenecteplase, low-dose tenecteplase, or no tenecteplase upfront if eligible for EVT or recently taking DOACs. Tenecteplase is administered as a single intravenous bolus shortly after randomization. The study design is open-label with blinded endpoint assessment and follows patients for 90 days after treatment or until death. During the study, patients will have their functional outcomes measured using the modified Rankin Scale at 90 days, with assessments done by telephone. Researchers will also track mortality, quality of life, serious adverse events, intracranial hemorrhages, and imaging outcomes related to brain infarcts and reperfusion success after EVT. Hospital stay length and ambulatory status at discharge will be recorded. Safety monitoring occurs up to 36 hours post-treatment, with imaging reviewed by blinded experts. The total participant involvement lasts up to 90 days from enrollment.

Researchers are evaluating the Small Steps for Big Changes SSBC program, a diet and exercise counseling initiative aimed at reducing the risk of developing Type 2 Diabetes T2D among adults with prediabetes. This study partners with YMCAs across eight Canadian provinces to scale up and assess both the implementation and effectiveness of SSBC in diverse urban communities. The research focuses on how well the program is delivered and its impact on patient health outcomes over time. Participants engage in the SSBC program, which includes six sessions over four consecutive weeks. Each session offers 20 to 30 minutes of counseling to build self-regulation skills for healthy eating and exercise, followed by 20 to 30 minutes of supervised aerobic exercise. The program is delivered by YMCA community facility trainers, and participants also complete three additional exercise sessions independently. There is no randomization all enrolled individuals receive the same intervention. During the study, participants are observed for up to two years after completing the program. Researchers measure changes in diabetes status, blood sugar levels, weight, fitness, diet, and exercise habits. They also track program adoption, attendance, delivery costs, and participant satisfaction. Assessments include health questionnaires, physical measures, and healthcare resource use, helping to understand both the clinical and cost-effectiveness of SSBC over time.