Guiyang

This observational study focuses on investigating the proportion of latent tuberculosis infection among students who have been in close contact with active tuberculosis patients in school settings. It aims to identify how common Mycobacterium tuberculosis infection is in these contacts, explore risk factors related to TB infection, and assess the health economic aspects of screening strategies for tuberculosis. Participants will be tested using the QuantiFERON-TB Gold (QFT) test to detect prior infection with Mycobacterium tuberculosis. Those who test positive will undergo additional evaluations including sputum Xpert MTB/RIF testing, physical examinations, chest CT scans, and sputum cultures as needed to distinguish latent TB infection from active tuberculosis. Chest X-ray scans are performed if the participant is older than 15 years and has a positive QFT result. During the study, participants will be monitored through these diagnostic tests and examinations to determine the presence of TB infection. Researchers will measure the prevalence of tuberculosis infection at baseline among school contacts. The study includes students aged 13 years and older who have had close contact with active TB cases in school environments such as classrooms or dormitories. Participation involves signing informed consent, with guardian involvement for minors.