Xiang Xi Tu Jia Zu Miao Zu Zi Zhi Zhou

Chronic subdural hematoma CSDH is a common neurosurgical condition where fluid collects between layers of the brains protective membranes, causing brain compression and neurological problems. This condition can be life-threatening if severe, and current treatments lack a clear standard due to uncertain long-term outcomes. Researchers are conducting a multicenter randomized trial to compare two surgical methods to find the best treatment approach for CSDH. The study compares neuroendoscopy-assisted hematoma drainage to conventional burr-hole drainage. Neuroendoscopy allows surgeons to see and remove the hematoma more thoroughly using a small bone flap and a visualized neuroendoscope, aiming to reduce residual hematoma and recurrence. Burr-hole drainage uses a single hole to irrigate and drain the hematoma. Both procedures involve continuous drainage for up to 48 hours post-surgery or until drainage stops naturally. Participants will be adults aged 18 to 90 with diagnosed CSDH requiring surgery. Researchers will assess recurrence rates, mortality, neurological function scales, quality of life, complications, drainage time, and hospital stay length over three months after surgery. Follow-up visits occur at Day 0, Day 2, Month 1, and Month 3 to monitor outcomes and safety. The total study duration per participant is three months post-operation.

Researchers are studying a new approach to improve language function in children aged 2 to 5 years with Global Developmental Delay GDD, a developmental disorder affecting multiple areas including language. The study aims to evaluate the effects of combining personalized language training with non-invasive, painless repetitive Transcranial Magnetic Stimulation rTMS targeted at brain regions responsible for language. About 50 children will participate in this randomized controlled trial conducted at Xiangxi Autonomous Prefecture Peoples Hospital. Participants will be randomly assigned to one of two groups. One group will receive personalized language training combined with high-frequency rTMS sessions, where magnetic pulses are delivered at 10 Hz with specific parameters for 20 minutes before each training session. The control group will receive only the individualized language training without rTMS. The intervention lasts for two weeks, followed by a two-week follow-up to assess the durability of any improvements. During the study, children will undergo language assessments using the Gesell Developmental Schedules to measure changes in language developmental quotient and the Sign-Significate Relations assessment to evaluate language developmental stage. Safety and tolerability will be monitored throughout the four-week period. The study includes baseline assessments at day 0, evaluations at the end of the two-week intervention, and again at the four-week follow-up to measure lasting effects of the combined therapy.