Pozega

Researchers are evaluating treatments for community-acquired pneumonia CAP, especially in patients admitted to intensive care units ICUs. This trial also adapts to study treatments for respiratory pandemics like COVID-19. The goal is to determine which treatment strategies improve outcomes for patients with severe pneumonia, using a flexible, ongoing approach that can test multiple therapies simultaneously and update as new information becomes available. Participants receive different treatment strategies based on random assignment to study groups. Treatments include various antibiotics, steroids, antivirals, immune modulators, anticoagulation methods, and ventilation strategies. Some treatment options have been closed to recruitment, reflecting the trials adaptive nature. The trial includes several domains targeting specific infections such as influenza and COVID-19, with dosing and duration guided by clinical practice and local guidelines. During the study, participants are monitored closely with assessments including survival up to 90 days, days alive without organ support in ICU, ICU and hospital length of stay, ventilator-free days, organ failure-free days, and quality of life up to 6 months. Researchers collect detailed data on patient outcomes, organ support needs, and hospital discharge status. The study runs until February 2028, with ongoing evaluation to improve pneumonia treatment strategies in ICU settings and during respiratory pandemics.

Researchers are comparing two local anesthesia methods to see their effect on pain after laser treatment for pilonidal sinus disease, a common condition affecting about 2% of the population, mostly men. The study aims to find out if there is a difference in pain levels after surgery using conventional local anesthesia or tumescent local anesthesia, which may provide longer pain relief and reduce bleeding. This is a prospective, randomized study taking place from September 2025 to August 2027 at a general hospital. Participants receive either conventional local anesthesia with 2% lidocaine injected into the surgical area or tumescent local anesthesia, which is a diluted anesthetic solution including lidocaine, epinephrine, and sodium bicarbonate, injected under the skin before laser treatment using a 1470-nm radial-emitting laser fiber. Both groups undergo the same laser treatment for pilonidal sinus. Randomization is done by sealed envelopes prior to surgery. Participants will have their pain assessed using a visual analog scale VAS before surgery and on the first, second, and seventh days after surgery. Data on pain scores and demographics will be collected anonymously and assessed without bias. The main outcome measured is pain on the first day after surgery. The study ensures voluntary participation with informed consent, and no additional risks beyond standard care are expected.