Damanhour

Researchers are evaluating the possible role of Fenofibrate in reducing peripheral neuropathy caused by the VRd regimen, which includes bortezomib, lenalidomide, and dexamethasone, in patients newly diagnosed with multiple myeloma. This study focuses on assessing neuropathy using standardized grading scales and questionnaires, along with biological markers such as Brain-derived neurotrophic factor BDNF and Neuro-filament light chain NfL. The trial compares two groups of patients receiving VRd treatment, one with Fenofibrate added and one without. Participants are randomly assigned to one of two groups the Fenofibrate group receives 6 cycles of the VRd regimen plus Fenofibrate 160 mg orally once daily during the treatment cycles the control group receives only the 6 cycles of the VRd regimen every 28 days. Bortezomib is given subcutaneously at specific days in each cycle, lenalidomide is taken orally for 21 days, and dexamethasone is administered orally on four days per cycle. The study interventions last through the 6 cycles of VRd treatment. During the trial, neuropathy severity is evaluated at baseline and after every two VRd cycles using the NCI-CTCAE criteria and a neurotoxicity questionnaire. Blood samples are collected to measure BDNF and NfL levels at the start and within one week after the final VRd cycle. Researchers monitor changes in neuropathy grades, questionnaire scores, and biological markers to understand the impact of Fenofibrate. Participants are followed throughout the treatment period, which lasts approximately six months.

This research aims to evaluate the effects of Pilates exercises on balance, fatigue, and quality of life in patients aged 20 to 50 years who have physical and functional limitations after renal transplantation surgery. Fifty patients of both genders participated, randomly assigned to two equal groups to compare combined Pilates and conventional physical therapy with conventional therapy alone. One group received Pilates exercises three times a week alongside a conventional physical therapy program including aerobic walking, low intensity strengthening, and stretching exercises, plus medical care, for 12 weeks. The control group received only the conventional physical therapy program and medical care for the same duration. Pilates exercises included warm-up, main strengthening exercises focusing on core and limb muscles, and relaxation phases. Participants were assessed before and after the 12-week intervention using the Borg Balance Scale for balance, the Modified Fatigue Impact Scale for fatigue, and the Kidney Disease Quality of Life self-report questionnaire. Researchers monitored adherence to the exercise programs and medical treatments throughout the study. The trial is randomized and double-blinded, with all assessments conducted at the start and end of the 12 weeks.