Luxor

This clinical trial focuses on men with erectile dysfunction (ED) who have not responded to PDE5 inhibitors. It aims to evaluate whether combining daily tadalafil 5 mg with on-demand sildenafil 100 mg improves erectile function better than on-demand sildenafil alone. The study also assesses the safety and tolerability of this combination therapy in this patient group. Participants will be randomly assigned to one of two groups: one receiving daily tadalafil 5 mg plus on-demand sildenafil 100 mg, and the other receiving daily placebo plus on-demand sildenafil 100 mg. The treatment period lasts 12 weeks, during which participants take their assigned medications as directed. Throughout the study, participants will undergo baseline assessments including medical history, physical exam, and lab tests. Follow-up evaluations at 4, 8, and 12 weeks include questionnaires measuring erectile function, assessments of erection hardness, and monitoring for any adverse effects. The main outcome measured is the change in erectile function from the start through 12 weeks of treatment.