Nasr City

This trial investigates transfusion strategies for younger patients aged 18 to 65 undergoing cardiac surgery with the use of cardiopulmonary bypass. It compares two common approaches to red blood cell transfusion thresholds to determine which is better for patients at moderate to high risk, focusing on important health outcomes after surgery. Participants are randomly assigned to one of two groups. One group receives a restrictive transfusion strategy, where transfusions are given only if hemoglobin levels drop below 75 gL during or after surgery. The other group follows a liberal transfusion strategy, with transfusions given at higher hemoglobin thresholds during surgery, in the intensive care unit, or on the ward. The study is open-label and conducted at multiple international centers. During the trial, researchers monitor participants for events such as death, heart attacks, kidney failure requiring dialysis, and neurological problems up to six months after surgery. They also track hospital stay length, infections, mechanical ventilation time, and other complications. Participants are followed closely through hospital discharge and for several months afterward to collect this important information.