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Found 2 Actively Recruiting clinical trials
Actively Recruiting
Healthy Volunteer
Researchers are evaluating the effectiveness of a new premixed bioactive bioceramic material called Neo-Putty as a pulp treatment in children's primary molars with carious pulp exposure. This randomized clinical trial compares Neo-Putty with the traditional formocresol (FC) pulpotomy technique. The study aims to determine whether Neo-Putty offers better clinical and radiographic success in preserving the vital pulp tissue while avoiding the toxic effects and reported side effects associated with formocresol. The trial includes two treatment groups. In the control group, a cotton pellet moistened with full-strength formocresol is applied for 5 minutes to the amputated pulp after bleeding stops, followed by coverage with an intermediate restorative material (IRM). In the intervention group, after removing the coronal pulp and achieving hemostasis, the pulp stumps are covered with Neo-Putty according to the manufacturer's instructions, then sealed with reinforced zinc oxide-eugenol (IRM). The study uses a randomized, parallel design with blinding of participants, guardians, and the statistician. Participants will be monitored clinically and radiographically at 3, 6, 9, and 12 months to assess treatment success. Success is defined by the absence of symptoms such as spontaneous pain, excessive bleeding, internal root resorption, bone destruction, swelling, or sinus tract. The study will provide important data on the safety and effectiveness of Neo-Putty compared to formocresol, potentially influencing pediatric dental care worldwide.
Actively Recruiting
Healthy Volunteer
Researchers are evaluating the clinical success and patient satisfaction of digital, conventional, and biomimetic approaches for restoring endodontically treated mandibular first permanent molars in patients aged 15 years and older. This randomized controlled trial compares the use of Lithium Disilicate Endo-Crowns, EverX Posterior with Vita Endo-Crowns, and EverX Posterior with Bulk-Fill Resin Restorations. The study aims to determine which technique offers the best long-term outcomes, including restoration durability and patient satisfaction. The trial involves two parallel groups with random assignment to different treatment methods. These include the use of CAD/CAM technology to prepare and place Endo-Crowns in a single visit, as well as biomimetic techniques using fiber-reinforced composites to restore the teeth conservatively and effectively. The treatments focus on preserving tooth structure, enhancing fracture resistance, and improving gingival health. Participants will be followed for 12 months with regular checkups at 3, 6, 9, and 12 months. During these visits, clinicians will assess the restorations using visual, tactile, and radiographic evaluations, including photographs and periapical X-rays. Patient satisfaction will be measured through questionnaires covering appearance, chewing ability, and overall satisfaction. All data will be securely collected and analyzed to determine clinical success and restoration survival.