Biarritz

Researchers are evaluating the effects of a triple therapy inhaler combining budesonide, glycopyrronium, and formoterol fumarate BGF MDI 32014.49.6 g compared to a dual therapy inhaler with glycopyrronium and formoterol fumarate GFF MDI 14.49.6 g on heart and lung outcomes in adults with Chronic Obstructive Pulmonary Disease COPD who have a higher risk for heart and lung events. This Phase III study is randomized, double-blind, and conducted at multiple centers, focusing on participants with COPD and elevated cardiopulmonary risk. Participants will receive either the triple therapy inhaler or the dual therapy inhaler, both administered twice daily. The study compares these two inhalers over a period of up to three years, monitoring for serious cardiac or COPD events. The trial includes careful evaluation of various heart and lung-related health events during this period. During the study, participants will be closely monitored through regular visits, assessments, and tests to measure lung function, heart events, and COPD exacerbations. Researchers will track the time until the first severe cardiac or COPD event and evaluate other cardiovascular and respiratory outcomes over up to three years. Participants will also be assessed for their ability to properly use the inhaler and adherence to the study protocol throughout the trial.

Researchers are studying type 2 diabetes T2DM, a common form of diabetes affecting many adults in France, often going undiagnosed for years due to its silent nature. This study aims to explore a different, more coordinated approach focused on prevention rather than treatment, given that lifestyle factors like diet and inactivity are major risks. The study addresses the high health and economic burden of diabetes, which affects millions and results in significant healthcare costs. The study compares standard care for type 2 diabetes with an additional personalized follow-up involving a dedicated study nurse who contacts participants every four months. Participants are randomized to either continue standard diabetes follow-up or receive this extra nurse support alongside their usual care. This behavioral intervention is designed to enhance prevention efforts through more frequent and personalized engagement. Participants will be involved in regular follow-ups for up to five years, during which their risk of developing diabetes is assessed using the FINDRISC score. The study will monitor participants health and lifestyle factors over time to evaluate the impact of the nurse-led intervention. Researchers will collect data on diabetes risk and study compliance while ensuring participant safety and confidentiality throughout the study duration.

This research aims to describe how patients aged 18 years or older with moderate to severe atopic dermatitis AD are managed with systemic therapy. It focuses on patients eligible for or currently receiving systemic treatments, following their care under real-world conditions. The study involves French dermatologists experienced in AD management, whether practicing in hospitals or private offices. Treatment decisions are made independently by the physicians and not influenced by the study enrollment. Participants will receive systemic treatments for AD prescribed by their doctors as part of routine care, with no investigational drugs involved. Information will be collected during regular visits according to usual clinical practice. The study will follow patients for one year, tracking their treatments and management without altering standard care. During the year, patients will be assessed at baseline, 6 months, and 12 months. Researchers will collect data on previous and current treatments, treatment adherence, changes in disease severity, itch, sleep disturbance, skin pain, quality of life, psychological health, work absences, and hospitalizations related to AD. This comprehensive follow-up aims to better understand how systemic therapies are used and their impact on patients in everyday clinical settings.

Researchers are studying the rate at which patients return to sports activities at least three years after receiving a total knee prosthesis. The study compares three different types of knee prosthesesmedial pivot, medial bearing, and cruciate retainingto understand how each design relates to patients return to sport. This observational study focuses on patients who had surgery between 2018 and 2020 and aims to gather detailed information about their sports activity post-surgery. The study involves three groups of patients, each having received one of the three types of knee prostheses mentioned. Patients are contacted by the investigator, informed about the study, and invited to participate. Participants complete questionnaires assessing their physical and functional abilities, which can be returned electronically or by phone. A secure email is created specifically for the study to manage communications and data collection. Participants will be assessed by telephone using various questionnaires on their physical and functional status. The main outcome measured is the rate of return to sport three years after surgery. The study includes a review of medical records and ongoing communication with patients to collect their questionnaire responses. This process helps researchers evaluate how well patients resume sports activities following the different prosthetic knee designs.

Researchers are evaluating the long-term outcomes of various shoulder replacement systems sold by FX SHOULDER SOLUTIONS. This observational study follows patients who have undergone shoulder arthroplasty, including total anatomical, hemi anatomical, or reversed procedures. The main goal is to measure the rate of revision surgeries over a 10-year period after the initial operation. Secondary goals include assessing shoulder movement, pain, function scores, implant positioning, complications, and surgeon feedback throughout follow-up visits. The study plans to include 1004 patients treated with one of 11 different shoulder implant types, covering a range of indications such as trauma, degenerative conditions, and revisions. Patients may be enrolled retrospectively or prospectively, with a preference for prospective recruitment. Participants are followed at scheduled intervals after surgery 6 weeks, 3 or 6 months, 1 year, 2 years, 3 years, 5 years, 7 years, and finally 10 years post-operation. During the study, patients will attend regular postoperative visits where their shoulder function is evaluated using standardized scores like QuickDASH, Constant-Murley, ASES, and Subjective Shoulder Value. Pain levels and radiological assessments of implant positioning are also performed at each visit. Researchers will monitor for any complications and collect qualitative feedback on the surgical instruments used. The study offers long-term monitoring of shoulder implant performance in real-life conditions over a decade.