Bretigny Sur Orge

The EXPLO-MITO study focuses on people affected by exercise heat stroke and healthy individuals, studying how their bodies regulate heat during physical activity. This observational study uses the Heat Tolerance Test HTT, which is a controlled treadmill walk in a hot environment to measure how well participants tolerate heat. The test aims to distinguish between those who are heat intolerant and heat tolerant by monitoring heart rate, body temperatures, skin blood flow, and sweat loss. Participants undergo several tests including the HTT, a bike stress test involving cycling with gas exchange monitoring, and a heat nociception test using infrared light to assess heat sensitivity. The HTT specifically involves walking at 5 kmh on a 2% slope in a 40C environment with 40% humidity while continuously measuring rectal temperature, heart rate, and skin temperature, and checking blood pressure every 30 minutes. The study includes a case group of heat stroke patients and a control group of healthy individuals. During the study, participants will be monitored closely with physiological measurements and tests to understand their heat regulation. Researchers will measure the percentage of heat intolerant individuals throughout the 48-month study period. The tests are designed to be safe and reproducible under controlled laboratory conditions. Participants exercise habits and medical history are also considered to assess their heat tolerance and recovery after heat stroke.