Corbie

Researchers are studying patients with heart failure with reduced ejection fraction (HFrEF) to understand how their ability to exercise, measured by peak oxygen consumption (VO2peak), changes during a phase II cardiac rehabilitation program. The study aims to link changes in VO2peak with the expression of specific circulating microRNAs, which may influence the body's response to exercise by affecting lung, heart, and muscle functions. Understanding these links may help identify which part of the oxygen transport system is most affected and personalize rehabilitation strategies. This study will involve 62 patients with HFrEF undergoing exercise-based cardiac rehabilitation. Before and after the program, researchers will measure peak oxygen uptake, heart function, brain and muscle oxygen levels, and circulating microRNAs through non-invasive tests during exercise. Participants will also perform a force-velocity test to develop a personalized resistance training plan. During the study, participants will have assessments including cardiopulmonary exercise testing and biomarker analysis to monitor changes in their physical condition and molecular markers. The main outcomes measured are changes in peak oxygen consumption and microRNA levels from baseline to after the rehabilitation. This detailed monitoring will help understand the physiological and molecular adaptations to exercise in heart failure patients over the course of their rehabilitation.