Fontainebleau

Researchers are evaluating how vaccine funding by the National Health Insurance affects vaccination coverage among patients targeted by current vaccination recommendations in outpatient consultations within four healthcare institutions in the Ile-de-France region in France. The study aims to determine if dedicated funding for vaccine procurement can improve vaccination rates for vulnerable patients at risk of infections such as pertussis and pneumococcal disease. It also seeks to understand the influence of socio-economic factors and changes in healthcare providers' practices on vaccination coverage and record-keeping. The study involves providing vaccines funded by the National Health Insurance to patients during outpatient consultations. It targets pneumococcal vaccination for eligible patients aged 18 and older and pertussis vaccination for pregnant women following French recommendations. Questionnaires are completed by both patients and healthcare providers to gather information on vaccination practices and status. The study focuses on patients seen in outpatient consultations at participating institutions and includes pregnant women in maternity wards during and after pregnancy. Participants will be monitored for vaccination status at 3 months and 18 months after vaccine availability to measure coverage rates for pneumococcal and pertussis vaccines. Researchers will use patient and provider questionnaires, digital vaccination records, and hospital software to track vaccinations and assess changes in healthcare practices. The study also examines socio-economic impacts and plans to share findings to potentially expand vaccine funding agreements across healthcare institutions. Participation involves outpatient visits, maternity follow-ups, and data collection over the study period.

Researchers are investigating kidney cancer through the UroCCR project, a national registry and research network in France dedicated to renal cell carcinoma (RCC). This platform collects detailed clinical, imaging, biological, and patient-reported data on kidney cancer from over 21,000 cases across 58 centers. The study aims to improve understanding of RCC management by integrating multidisciplinary care data, biological samples, and linking with national health datasets to support translational research, clinical evaluation, and social science studies. The study compares two surgical treatments for kidney cancer: radical nephrectomy and partial nephrectomy, with the choice of surgery made according to surgeon judgment. It follows patients over long periods, monitoring outcomes and complications after surgery. This national collaboration includes digital tools like perioperative monitoring and machine learning models to predict recurrence and survival. The network also supports ancillary studies, including retrospective and prospective clinical trials, to advance personalized treatment strategies. Participants provide comprehensive data on their clinical status, treatments, and quality of life. Researchers assess complications at multiple time points: 3, 6, and 12 months post-surgery, then yearly for 5 years, and every 2 years for up to 10 years. The study evaluates real-world outcomes in kidney cancer care, linking clinical information with biological samples and national health data, while ensuring standardized procedures, ethical oversight, and high data quality through robust governance.