Guilherand Granges

This research aims to understand how the quality of life changes for women who have undergone surgery for breast cancer. It focuses on their entire care journey, especially considering their access to supportive oncological care both within and outside the healthcare facility. The study specifically involves women diagnosed with invasive breast cancer and looks to explore factors affecting their well-being after surgery. Participants in the study will complete several quality of life questionnaires, including FACT-B, EORTC QLQ-C30, QIC, BRIEF COPE, HADS, and QSSS-C. These questionnaires help assess various aspects of their physical, emotional, and social health during their treatment and recovery process. The study compares how access to additional supportive care affects these quality of life measures. Women taking part will be monitored over a 12-month period during which they will regularly complete the questionnaires. Researchers will evaluate their responses to understand changes in quality of life over time. The study also ensures that participants meet certain health and language requirements and that they can complete the questionnaires, while excluding those with conditions or circumstances that might interfere with treatment or data collection.

Researchers are evaluating treatments for men aged 45 to 75 with favorable intermediate risk prostate cancer. This study compares focal High-Intensity Focused Ultrasound (F-HIFU) with radical prostatectomy (RP) to see which treatment is more cost-effective and provides better quality of life over 24 months. The trial is multicenter and randomized, initially with equal groups but later adjusted to a 2:1 ratio favoring F-HIFU, with follow-up extending to 48 months using health system data to monitor costs, mortality, and cancer control. Participants receive either F-HIFU using the Focal-One4 machine under local or general anesthesia, targeting specific prostate areas, or undergo radical prostatectomy performed by open, laparoscopic, or robot-assisted surgery under general anesthesia. Treatments follow standard procedures at each center, with randomization done up to 2 months before the procedure. During the study, participants will be monitored through medical records and health system data without extra visits. Researchers will assess the cost-effectiveness of treatments based on quality-adjusted life years (QALYs) at 24 months. Safety, cancer control, and mortality will also be tracked up to 48 months. The total participation time includes treatment and long-term follow-up using existing health data sources.

Multicenter phase II trial evaluating different strategies of pre-specified fluoropyrimidine-dose adjustment according to \[U\] in DPD-deficient patients with gastrointestinal cancer.

Researchers are gathering long-term real-life clinical data on patients who have undergone hip joint replacement or repair using medical devices from FH ORTHO Company. This study focuses on the clinical safety and performance of these devices when used as approved, including different versions and combinations of implants used in arthroplasty and trauma repair. The study operates as a dynamic cohort, allowing new participants to join to replace those who leave early. The intervention involves hip surgery using one or more FH ORTHO Company devices, as applied by surgeons at participating centers. The study includes patients who have these devices implanted in accordance with approved instructions. Data collection is supported by electronic systems for surgeons (electronic Case Report Form) and patients (Electronic Patient Reported Outcome via phone, tablet, or computer). Participants will be followed for up to 15 years to monitor the survival rate and revision of the medical devices. The study collects ongoing clinical data through patient and surgeon reports, focusing on device performance and safety over the long term. Consent and local regulations regarding patient inclusion apply, with some countries requiring social insurance for participation.

It is admitted that: * Bioabsorbable interference screws are frequently used for graft attachment in knee cruciate ligament reconstruction, * Bioabsorbable pins are indicated for the realignment and fixation of epiphyseal fractures, osteotomies, arthrodesis and bone grafts of toes, * Non-absorbable suture is usually used for the repair and the reinforcement of ligaments or tendons structures during surgery procedures, * Anchor devices are usually used for the repair of rotator cuff tendons and biceps tenodesis. Furthermore, resorption properties of many available devices (screws, pins) that are marketed as bioabsorbable may be different and not always very well defined. This retro-prospective study is performed to confirm the safety and performance of TEKNIMED sports surgery products in their current clinical use. Studied products include - but are not restricted to - the following TEKNIMED products: * EUROSCREW® NG * ISOFIX® * SUTUR'LINK® * A'LINK'S® * BIORESORBABLE PINS And following associated TEKNIMED instrumentation: * ACL Instrumentation * A'LINK'S® Instrumentation * STAINLESS STEEL PINS

This research aims to assess the long-term performance and safety of ATF Implants and Lapé Médical devices used in hip replacement surgeries, including total hip arthroplasty or hemiarthroplasty. It is a prospective, observational, multicenter study designed to collect clinical evidence over a 10-year period. The study focuses on patients receiving these specific hip prostheses to better understand their durability and safety outcomes. The study involves patients undergoing hip replacement surgery with implants manufactured by ATF Implants and Lapé Médical. Surgeons will select the most appropriate prosthesis based on individual patient factors and device instructions at the time of surgery. The evaluation includes monitoring both the hip prostheses and the surgical instruments used for their placement throughout the 10-year follow-up. Participants will be followed before and after surgery with regular evaluations by surgeon-investigators using established orthopedic criteria. Data on complications, adverse effects, and prosthesis performance will be recorded. The main outcome measured is the long-term survival rate of the implants over 10 years. Additional assessments will include safety, performance, and user feedback on the devices and instruments during the study period.