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Researchers are studying the long-term health outcomes of people living with HIV who are treated with antiretroviral therapy (ART). While ART has helped make HIV a chronic condition with survival rates close to the general population, those living with HIV still face higher risks of other health problems, including immune system issues, cardiovascular disease, cancer, and complications from aging. The study also looks at psychiatric, neurological, and social factors affecting these individuals, aiming to better understand overall health beyond just physical symptoms. Participants in this study receive follow-up care based on national guidelines, where demographic, clinical, biological, and treatment data are collected at each hospital visit using a standardized questionnaire. All health events are recorded according to the International Classification of Diseases (ICD-10). Additionally, a biobank of samples is collected from consenting participants at entry and every two years thereafter to support further research. People in the study will be monitored for up to four years, with annual assessments of socio-demographic characteristics and health status. The study tracks the development of new health problems, monitors the effectiveness and side effects of ART regimens, and gathers comprehensive data on participants’ clinical management. This long-term observation aims to provide a detailed understanding of morbidity and mortality risks in treated HIV patients.