Mont Saint Aignan

Researchers are conducting a French prospective observational study to understand how patients aged 18 years and older with moderate to severe atopic dermatitis (AD) are managed when eligible for or currently receiving systemic therapy. The study aims to describe treatment patterns, including previous and current therapies, and monitor drug survival and compliance over time. Experienced dermatologists in hospital and office settings will participate, ensuring treatment decisions reflect real-world clinical practice. Patients will be followed for one year under routine care, with systemic treatment decisions made solely by their physicians independent of study enrollment. The study does not involve specific interventions or changes in treatment but observes the use and management of systemic therapies for AD, including topical corticosteroid use and other systemic options. Participants will complete questionnaires and undergo assessments at baseline, six months, and twelve months. Researchers will collect data on previous and current treatments, therapeutic management of atopic comorbidities, drug survival changes, and treatment adherence. The study focuses on gathering real-life information on systemic therapy use and patient outcomes over the 12-month follow-up period.

Researchers are studying children and adolescents placed full-time in Child Protective Services in the regions of Seine-Maritime and Eure, as well as in nurseries in Le Havre or Rouen. The study aims to assess the prevalence and changes over time of medical and psychological characteristics, focusing on behavior, development, and mental health issues in these young individuals, grouped by age. The goal is to understand vulnerability and resilience factors that influence their developmental paths and adaptive methods during their time in the child welfare system. Participants undergo several assessments starting shortly after their arrival in the care structure. At the beginning (M0), a psychologist conducts an interview that includes cognitive testing, psychiatric classification, and psychological evaluations. Follow-up assessments occur at 12 months (M12) and 24 months (M24) after placement, focusing on psychiatric classification and psychological evaluations to monitor changes in mental health status over time. Throughout the study, researchers collect data on psychiatric disorders using criteria from the DSM 5 at inclusion, 1 year, and 2 years after placement. This includes detailed psychological assessments and cognitive tests administered by a psychologist. The study tracks the presence and nature of psychiatric disorders and other psychological factors to understand how these evolve during the child or adolescent's time in protective care. The total participation lasts for two years with ongoing monitoring at set intervals.