Montigny Le Bretonneux

Researchers are investigating how changes in NAD+ metabolism might affect the risk of acute renal failure in patients admitted to intensive care. Acute renal failure is common and serious among intensive care patients, leading to higher risks of death and complications like chronic kidney disease and cardiovascular problems. Malnutrition, especially vitamin deficiencies, may increase this risk, and recent studies suggest that problems with NAD+ production play a role in kidney failure. The study involves collecting a 5 mL urine sample from patients when admitted to intensive care to analyze the Quinolinate/Tryptophan ratio related to NAD+ metabolism. This measurement aims to identify a link between this metabolic marker and the development of acute renal failure. Additionally, a follow-up phone call at day 28 will gather information on patient recovery, hospital stay length, vital status, any adverse events, and other treatments received. Participants will be monitored for the occurrence of acute renal insufficiency within 2 days of admission. The research includes patients over 18 years old admitted for conditions with a high risk of acute renal injury. The study collects clinical data and outcomes to better understand the role of NAD+ metabolism in kidney health during intensive care. Follow-up and safety monitoring continue through the 28-day post-admission period.

Chronic insomnia affects a significant portion of the French population, with around 15% to 20% experiencing this condition. The study aims to evaluate the effectiveness of auriculotherapy, specifically cryo-auriculotherapy, for treating chronic insomnia. This condition is typically managed by general practitioners using medications such as benzodiazepines and Z-drugs, but concerns exist regarding their long-term use due to side effects and dependency risks. The study focuses on patients diagnosed with chronic insomnia according to DSM-5 criteria and monitored in outpatient clinics at Foch Hospital or other participating centers. Participants will be divided into two groups: one receiving cryo-auriculotherapy using a device with nitrous oxide on 10 ear points, and the other receiving a sham treatment with the same device but without nitrous oxide. Each group will have three treatment sessions spaced one month apart. This setup allows comparison between real and sham interventions to assess the impact on sleep improvement. During the study, researchers will track insomnia improvements after three months of treatment. Participants will complete questionnaires like the Insomnia Severity Index, and adherence to treatment and study protocols will be monitored. Safety and any side effects will also be observed throughout the study period, which includes regular assessments to measure treatment effectiveness and participant well-being.