Palaiseau

Researchers are evaluating the safety and performance of hyaluronic acid-based dermal fillers designed to enhance facial features such as the lips, perioral lines, nasolabial folds, cheeks, and infraorbital hollows. This post-market study aims to confirm how long the effects of these fillers last when used in real-life conditions on adults aged 18 years and older seeking aesthetic treatment. The fillers use COLD-X1932 technology by Symatese to modify skin anatomy and facial appearance. Participants will receive facial injections of these dermal fillers and attend follow-up visits every 6 months for up to 24 months. During these visits, the investigator will assess the treated areas using specific 5- or 6-point scales to determine if the area has returned to its pre-injection state. If desired, participants may receive retreatment at the 12- or 18-month follow-up if their treated areas have returned to baseline. Throughout the study, participants will undergo simple clinical examinations to monitor safety and performance. They will also evaluate their own aesthetic improvement compared to before treatment and report the pain level experienced during the initial injection. The main outcome measured is the number of patients whose treated areas return to their baseline state at each follow-up visit conducted at 6, 12, 18, and 24 months.