Pont Audemer

This research aims to evaluate the real-life effectiveness, safety, usage, tolerance, and satisfaction of four CE-marked isotonic and hypertonic seawater-based nasal sprays. It focuses on infants, children, adults, and pregnant or breastfeeding women who suffer from acute and chronic sinonasal conditions such as upper respiratory tract infections, COVID-19, bronchiolitis, allergic rhinitis, chronic rhinosinusitis, and post-surgery recovery. The study seeks to answer key questions on how well these nasal sprays work and how safe and satisfactory they are in everyday use. Participants will use one of four nasal sprays designed for different age groups and indications. The sprays are applied by spraying 1 to 3 seconds into each nostril multiple times daily, depending on the product and condition. Treatment for nasal symptoms ranges from 2 to 6 times a day, while hygiene and prevention uses are less frequent. The nasal sprays are used according to their intended purpose and population, including special instructions for babies, children, and adults. During the study, participants or their parents/caregivers will perform nasal washes following healthcare provider advice and complete online questionnaires about their symptoms and experience. Researchers will monitor nasal symptom improvement over 5 days for acute conditions and up to 14 days for chronic conditions. The study includes assessments of nasal symptom intensity, nasal breathing impairment, safety, and user satisfaction. Participants are expected to comply with study requirements for up to 3 months and have daily internet access for questionnaire completion.

Researchers are evaluating a screening method for hepatitis B, hepatitis C, and AIDS viruses among drug users. The study aims to identify active infections of these viruses using a simple blood collection technique. It focuses on individuals with a history of intravenous or nasal drug use, including those receiving opiate substitution therapy. The study uses a Dried Blood Spot method for blood collection to screen participants for hepatitis B, hepatitis C, and AIDS viruses. This approach allows for easier sample collection and testing in this population. The intervention involves collecting blood samples on special filter paper to detect active infections. Participants are involved in one screening visit where their blood is collected using the Dried Blood Spot method. Researchers will assess the presence of active hepatitis B, hepatitis C, and AIDS infections on the first day. The study monitors the number of individuals with active infections as primary outcomes. The total participation time is focused on this initial screening event.