Romagnat

Childhood obesity is a significant public health concern, with rising rates in developed countries. Obese children and adolescents often have low vitamin D levels, which can contribute to chronic diseases like diabetes and cardiovascular problems. This research aims to identify the best vitamin D supplementation regimen to increase serum vitamin D levels in obese children and adolescents aged 5 to 18 years, addressing the lack of data on proper dosing in this population. The study is a phase 3 randomized clinical trial comparing two oral vitamin D supplementation methods. Participants will receive either a monthly bolus of cholecalciferol (50,000 IU initially and another 50,000 IU after 6 weeks) or a daily dose of 1,200 IU cholecalciferol (4 drops) for 3 months. These two regimens will be compared to determine which better corrects vitamin D deficiency in obese children and adolescents. The study evaluates the effects of these supplementation schedules on vitamin D levels and related health markers. During the study, researchers will measure the proportion of patients achieving vitamin D serum levels between 50 and 120 nmol/L at 3 months. Assessments may include blood tests to monitor vitamin D, calcium, and parathyroid hormone levels, along with evaluation of bone health markers. Participants' adherence and safety will be monitored throughout the trial, which aims to provide clear guidance on vitamin D supplementation dosing in this population.