Saint Amand Les Eaux

This research aims to evaluate treatments for gambling disorder GD, an addictive condition characterized by craving that can lead to relapse. The trial compares Cognitive-Behavioral Therapy CBT combined with Virtual Reality Exposure Therapy VRET to CBT with imaginal exposure therapy. Both approaches target craving responses triggered by gambling-related cues, with the goal to reduce GD symptoms. The study is a multicenter, randomized, controlled, non-inferiority trial to determine if VRET is at least as effective as imaginal exposure. Participants receive 12 treatment sessions over about 6 months, either CBT with VRET or CBT with imaginal exposure. VRET uses simulated gambling environments to closely mimic real gambling situations, while imaginal exposure involves mentally confronting gambling cues. Both methods aim to help patients reduce craving by addressing classical conditioning between cues and craving. The study compares the two approaches for symptom reduction, gambling behavior, craving levels, anxiety, depression, and treatment quality. Throughout the study, participants undergo assessments including the South Oaks Gambling Screen SOGS at baseline, end of treatment, and several follow-ups up to 12 months post-treatment. Additional measures include gambling frequency, money spent, craving episodes, cognition related to gambling, and mood symptoms. Attendance, safety, and symptom changes are monitored for approximately 18 months, providing comprehensive data on the effects of the therapies over time.