Saint Raphael

Researchers are comparing two methods for the second reading of screening mammograms in women aged 50 to 74 as part of a breast cancer screening program. The study aims to determine if the AI-assisted reading process is not worse than the standard radiologist reading and if it may be more cost-effective. It focuses on mammograms deemed normal or showing benign lesions from the first reading. Participants mammograms undergo two review paths the standard second reading by a certified radiologist, and an AI-assisted reading where mammograms flagged as suspicious by the AI are then reviewed by a radiologist. The final decision is based on the more concerning assessment from either method. Women will be recalled for further exams if either reading indicates suspicion. During the study, participants receive screening mammograms and their results are monitored for recall rate, cancer detection, sensitivity, specificity, economic impact, time to results, and reading time. The study will follow up for up to 48 months to measure these outcomes. Participants must consent and meet eligibility requirements related to health, imaging quality, and availability for the study duration.

This research aims to study people who have had their first episode of symptomatic deep vein thrombosis DVT in their lower limbs to understand the risk and severity of post-thrombotic syndrome PTS, the most common long-term complication of DVT. The study focuses on evaluating how the amount of thrombosis blood clot burden measured by the Venous Volumetric Index VVI on ultrasound relates to the development and severity of PTS assessed by the Villalta scale over 6 months. Participants will be followed at multiple times around 1 week, 1 month, 3 months, and 6 months after diagnosis. At each visit, doctors will assess symptoms and signs to calculate the Villalta score and perform venous ultrasounds to measure thrombosis burden using the VVI. Blood samples will be collected at several visits to study inflammation, coagulation, and clot breakdown factors. Quality of life questionnaires will also be completed at 3 and 6 months. During the study, symptom assessments, ultrasound exams, blood tests, and questionnaires will help researchers understand how the thrombosis burden at baseline and over time relates to the occurrence and severity of PTS. The study ends with the 6-month visit. Researchers will monitor the presence of moderate to severe PTS and changes in clot burden to identify important prognostic factors that may guide future prevention and treatment strategies.