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Low back pain is a common condition affecting about 23% of the general population and can lead to challenges such as psychosocial difficulties and prolonged inability to work. In France, treatment usually involves general practitioners and sometimes physiotherapists. Researchers are evaluating whether coordinated care involving general practitioners, physiotherapists, and occupational health services can improve the management and outcomes for patients with subacute or recurrent acute low back pain compared to standard care. The study compares two approaches: coordinated care and standard care. Coordinated care includes early contact with occupational health services initiated by the general practitioner and the use of an occupational retention tool. Patients in this group also receive an active physiotherapy program consisting of 15 individual, intensive, and regular rehabilitation sessions lasting one hour each, scheduled two to three times per week. This approach is deployed at the territory level to assess its impact on patient outcomes. Participants will be followed for one year after enrollment. During this time, researchers will monitor the perceived inability to work as the primary outcome. The study involves regular assessments and tracking of patient progress to evaluate the effectiveness of coordinated care in reducing prolonged disability related to low back pain. Overall, the study aims to improve the care pathway and reduce the risk of long-term disability for patients in primary care settings.

Researchers are evaluating two blood tests, eLIFT and FibroMeter, to screen for advanced liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) and/or alcoholic liver disease (ALD) in primary care settings. These chronic liver diseases are common and can lead to serious complications if advanced fibrosis is not detected early. General practitioners often find it challenging to identify patients with advanced fibrosis because routine exams and tests may appear normal. The study compares the eLIFT test, designed for easy use by general practitioners with simple calculation, to the more specialized FibroMeter test. Both tests are blood-based and aim to detect advanced liver fibrosis. Patients may also undergo elastography, a device-based liver stiffness measurement, or liver biopsy if needed. The study is conducted in primary care centers where patients with NAFLD and/or ALD will be screened using these tests. Participants provide blood samples and undergo clinical evaluations during the study. Researchers will measure how sensitive each test is in detecting advanced liver fibrosis. The study includes collecting blood samples at local laboratories and monitoring outcomes such as test sensitivity on the same day. The total participation timeframe includes initial screening and diagnostic testing procedures within one day.