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Researchers are studying prostate cancer patients undergoing radical prostatectomy to compare three surgical methods robot-assisted laparoscopy, conventional laparoscopy, and laparotomy. The study aims to evaluate the impact of these techniques on urinary and erectile functions, as well as their cost-effectiveness and long-term outcomes. This large, multicenter prospective observational study responds to previous concerns about the lack of high-quality evidence for robot-assisted surgery in prostate cancer treatment. Participants will undergo one of the three prostatectomy procedures robot-assisted laparoscopy, conventional laparoscopy, or laparotomy. Urinary and erectile functions will be assessed before and after surgery using standardized scores like the EPIC 50 and the International Index of Erectile Function IIEF-5. Outcomes including urinary incontinence, erectile dysfunction, and prostate-specific antigen PSA levels will be followed for up to five years. Cost-effectiveness will be evaluated at 12 months using the EQ5d-5L score. Throughout the study, participants will be evaluated at multiple time points, including 45 days and up to five years after surgery, to monitor urinary and erectile functions and other prostatectomy-related effects. Assessments involve questionnaires and clinical measurements. This comprehensive follow-up is designed to help determine the benefits and risks of each surgical approach, supporting informed decisions for patients and healthcare authorities. The study excludes patients without French health insurance or those unable to consent, focusing on adult males scheduled for prostatectomy.

Researchers are studying the potential benefits of outpatient care for patients with acute uncomplicated appendicitis treated by laparoscopic appendectomy. This research aims to compare outpatient care with conventional hospital care to see if outpatient care is not worse in terms of overall morbidity and mortality within 30 days after surgery. The study is motivated by the need to optimize care pathways, reduce hospital stays, improve patient satisfaction, and lower healthcare costs, especially important during the COVID-19 pandemic. The trial compares two treatment groups one receiving ambulatory appendectomy where surgery is done in an outpatient surgery unit and patients are discharged the same day, and the other receiving conventional appendectomy where surgery occurs in the digestive surgery department and patients stay overnight for observation before discharge. The study evaluates outcomes up to 30 days after surgery, including hospital stay length, rehospitalization rates, complications, re-interventions, patient satisfaction, quality of life, and economic impacts. Participants will undergo assessments before and after surgery, with monitoring of clinical outcomes, patient satisfaction, and quality of life at 7 and 30 days post-operation. Researchers will also track safety, the rate of conversion from outpatient to conventional care, and costs associated with each care pathway. The total study participation includes follow-up for 30 days after surgery to assess the main and secondary outcomes.

Endometriosis is a complex gynecological condition affecting about 10% of women of reproductive age, often causing severe pain during sexual intercourse that impacts sexual health and quality of life. This study evaluates the impact of a specialized kit developed to help women manage sexual pain related to endometriosis, using the Sexual Activity Questionnaire SAQ to measure sexual functioning and pain. The study compares two groups one receiving the specialized kit and one continuing their usual routine without the kit. The kit includes the Endo-Sexo Guide book explaining sexual pain mechanisms and solutions, the Endo Doute app for tracking pain and sexual activity, and practical tools such as an endo-vaginal TENS device, penis rings, hyaluronic acid suppositories, CBD lubricant gel and oil, plus dietary supplements. Patients choose how and when to use these tools independently. Participants will be evaluated over three months, with measures including sexual quality of life, pelvic pain, and the use of the kits tools. The study will monitor the need for additional medical care and any treatment-emergent adverse events. Data collection involves regular use of the app and questionnaires, aiming to assess how the kit affects patients ability to manage pain and improve their sexual quality of life.