Dornstadt

Researchers are characterizing patients with steatotic liver disease (SLD) in Germany through the German SLD-Registry, a project managed by the German Liver Foundation. This observational study aims to document the natural course of SLD and gather data on comorbidities, genetic variants, liver diagnostics, lifestyle factors, and quality of life. The study is financially supported by several pharmaceutical companies and focuses on patients diagnosed based on specific liver and metabolic evaluations. Participants' data collected includes physical exams and vital signs like age and weight, comorbid conditions such as diabetes and cardiovascular disease, and treatments related to SLD. Laboratory tests including liver function and creatinine levels are recorded alongside genetic information like PNPLA3 variants. Liver diagnostics involve histology and ultrasound findings, and lifestyle details such as alcohol intake and physical activity are documented. Quality of life is assessed through the SF-36 questionnaire. During the study, researchers monitor the progression of liver fibrosis, activity of metabolic dysfunction-associated steatohepatitis (MASH), cardiovascular events, and tumor diseases over approximately one year. The study involves regular assessments to track these outcomes and gathers comprehensive medical and lifestyle data to better understand SLD and its impacts.