Chandrapur

This research aims to evaluate the neurodevelopmental outcomes at 22 to 26 months of age in term or late preterm infants who were non-vigorous at birth. The study compares infants who received umbilical cord milking (UCM) with those who underwent early cord clamping (ECC) to assess differences in survival and neurodevelopmental impairment. It builds on the original CORDMILK trial and focuses on infants affected by conditions like hypoxic-ischemic encephalopathy and birth asphyxia. The intervention being studied is umbilical cord milking, where the umbilical cord is grasped and blood is pushed toward the infant four times before clamping, completing the procedure in 10-15 seconds. This method is compared to early cord clamping. The study follows infants from the original CORDMILK trial, focusing on their outcomes at 22 to 26 months of age. Participants will be assessed using standardized neurological and developmental tools to measure survival and neurodevelopmental outcomes at 22 to 26 months. The study involves follow-up evaluations to monitor the infants' progress and development over this period. No specific exclusion criteria are listed, and the study includes infants enrolled in the original trial who were non-vigorous at birth.

Premature birth is a leading cause of death in children under five years old, with around 15 million premature infants born worldwide annually, including many in India. This trial investigates whether umbilical cord milking (UCM) compared to early cord clamping can reduce in-hospital mortality in non-vigorous preterm infants born between 30 and 34 weeks of gestation. The study aims to provide evidence to support changes in guidelines for preterm infant care during delivery. Participants will be randomly assigned to either early cord clamping or umbilical cord milking, where the cord is squeezed four times to push blood toward the infant before clamping. This simple procedure takes 1 to 15 seconds and delivers placental blood transfusion. The trial is conducted across multiple centers with approximately 800 preterm infants enrolled. During the study, infants will be monitored from birth until hospital discharge or death, up to 12 weeks, to assess in-hospital mortality. Researchers will observe outcomes related to the different cord management techniques to determine their impact on survival rates. This low-cost intervention could offer a valuable option for improving outcomes in preterm infants requiring immediate resuscitation.