Tangerang City

Researchers are investigating the cardiovascular disease CVD risk profile among adults newly diagnosed with type 2 diabetes mellitus T2DM in Southeast Asia. This observational study uses retrospective chart reviews from five Southeast Asian countries to understand how CVD risk is distributed in these patients, based on data from the year before diagnosis and about the first year after diagnosis. The study focuses on adults aged 40 to 69 years who have recently started anti-hyperglycemic treatment. Participants are identified based on their diagnosis of T2DM between January 2022 and December 2023. The study does not involve any treatment administration as it is observational, relying on existing health records. Researchers collect data on cardiometabolic profiles at baseline, including measurements such as blood pressure, waist and hip circumference, height, weight, cholesterol levels, blood sugar levels, kidney function markers, and classification into CVD risk categories. During the study, participants medical records are reviewed to gather baseline measurements at the index date or within the previous 12 months if unavailable on the index date. The main outcomes measured include systolic blood pressure, lipid profiles, glycated hemoglobin, fasting glucose, kidney function tests, and CVD risk categorization. The study tracks participants health status for up to one year following their diagnosis to analyze cardiovascular risk factors and outcomes.

This trial is for adults who have had an acute ischemic stroke caused by a blood clot blocking a brain vessel. It focuses on people whose stroke occurred or was discovered more than 4.5 hours ago, including those who woke up with stroke symptoms. The study aims to find out if the medicine tenecteplase helps recovery when given after this 4.5-hour window, compared to standard medical care. Tenecteplase is already used within 4.5 hours after stroke onset, but this study tests its effect when given later. Participants are randomly assigned to one of two groups one receives a single injection of tenecteplase into a vein, and the other receives the usual standard treatment. Both groups have an equal chance of receiving either treatment. The study lasts about three months, starting with approximately one week of hospital stay. During the study, participants have seven clinical examinations or visits, with the final two visits conducted remotely from home to allow for easier participation. Throughout the study, doctors regularly assess participants recovery using a scale that measures disability and dependence in daily activities. They also monitor overall health and record any side effects. The main outcome measured is the level of recovery 90 days after treatment, comparing the two groups. This includes neurological improvement, bleeding events, and survival over the study period.

Researchers are evaluating the safety, tolerability, and effectiveness of adding metformin to standard multidrug therapy MDT for patients newly diagnosed with multibacillary leprosy. This double-blind, placebo-controlled Phase 2 trial aims to see if metformin can reduce leprosy reactions, nerve damage, and corticosteroid use while assessing immunological responses. The study is supported by the Leprosy Research Initiative and conducted in Indonesia with participants aged 18 to 65. Participants will be randomly assigned to receive either metformin or a placebo once daily. Metformin dosing starts at 500mg for two weeks, then increases to 1000mg for 22 weeks, alongside 48 weeks of standard MDT. The placebo group receives matching tablets to maintain blinding. The trial plans to enroll 166 patients to compare clinical outcomes between the two groups. During the 48-week study, participants will be regularly monitored for leprosy reactions, adverse events, nerve function, corticosteroid use, and quality of life through clinical assessments and questionnaires. The primary outcomes include the proportion of patients experiencing leprosy reactions and adverse events within specified timeframes. Secondary outcomes focus on reaction severity, timing, frequency, and impact on daily living. Safety and tolerability will also be closely observed throughout the study period.

This clinical trial evaluates the effectiveness of two medicines, tegoprazan and lansoprazole, in healing bleeding peptic ulcers in adults in Indonesia. The study focuses on determining which medicine better promotes ulcer healing after 2 weeks of treatment. This research is important because while lansoprazole is a commonly used acid-suppressing drug, tegoprazan represents a newer class that may work more quickly and effectively, but has not been directly compared to lansoprazole for this condition before. Participants will receive initial stabilization with IV fluids and blood transfusions if needed, along with high-dose acid-reducing therapy for the first 72 hours. They will have a gastroscopy within 24 hours of hospital admission for diagnosis and treatment of bleeding. Then, participants will be randomly assigned to take either a 50 mg tegoprazan tablet with a placebo capsule or a 30 mg lansoprazole capsule with a placebo tablet once daily, 30 minutes before breakfast, for 14 days. If they test positive for H. pylori infection, they will receive additional triple therapy. A second gastroscopy will be performed after 14 days to check ulcer healing. Throughout the study, participants will be monitored daily for symptoms and any rebleeding. They will be reminded to take their medication and schedule the follow-up gastroscopy. Researchers will assess the healing of ulcers based on the second gastroscopy and measure the mucosal healing rate 15 days after treatment starts. Safety and rebleeding rates within the 14-day treatment period will also be tracked. The entire participation lasts about two weeks of treatment plus follow-up evaluations.