Camposampiero

This research aims to study the epidemiology of invasive bacterial diseases caused by Streptococcus pneumoniae pneumococcus, Neisseria meningitidis meningococcus, and Haemophilus influenzae hemophilus. These infections can cause severe illness and serious complications. The study focuses on monitoring these infections to guide public health efforts, evaluate vaccine impacts, and plan prevention and treatment strategies by identifying circulating strains and assessing vaccine failures. The study uses molecular diagnostic testing to identify these bacteria from blood samples, even when traditional culture methods may fail due to prior antibiotic use or sample handling issues. Pediatric and adult patients diagnosed with invasive bacterial diseases caused by these pathogens are included. This approach enables more accurate detection and characterization of the bacteria. Participants diagnosed with these invasive bacterial infections will have their samples analyzed using molecular methods. Researchers will monitor the incidence rates of these infections in children, the distribution of bacterial types, and the proportion of cases preventable by vaccination. The study will also assess vaccine failure rates. The average study duration for outcome measurement is about one year, supporting improved surveillance and public health interventions.

Researchers are investigating the impact of the timing of minimally invasive surgery after neoadjuvant chemoradiotherapy for rectal cancer. This multicenter, randomized controlled trial aims to determine whether delaying surgery from the standard 8 weeks to 12 weeks influences the pathological complete response pCR, disease-free survival DFS, and overall survival OS in patients with locally advanced rectal cancer. The trial also explores the quality of life QoL outcomes related to these treatment intervals. Participants are randomly assigned to one of two groups one undergoes minimally invasive surgery, including robotic-assisted or standard laparoscopic procedures, 8 weeks after chemoradiation, and the other 12 weeks after. The trial includes surgeries such as low anterior resection, intersphincteric resection, or abdominoperineal resection using various robotic systems or standard laparoscopic methods. The study involves a recruitment period of 5 years with follow-up continuing for 5 years after the last patient is randomized. During the study, patients will complete questionnaires and undergo preoperative assessments including CT-scan and MRI to confirm tumor staging. Researchers will monitor outcomes including pathological response, survival rates, and quality of life. Patients provide informed consent and are evaluated for eligibility before randomization, which occurs near the start of neoadjuvant treatment. Safety and treatment effects are tracked throughout the study period, which may last up to 10 years including follow-up.