Fiorenzuola D Arda

Researchers are evaluating the impact of a personalized technology-based rehabilitation program on upper limb motor function and capacity recovery in adults who have experienced a stroke. Stroke often results in upper limb impairments like weakness, altered muscle tone, and coordination loss, which affect daily activities. This study aims to better understand how technology-assisted therapies can improve rehabilitation outcomes alongside conventional treatments. The intervention includes a customized upper limb rehabilitation program using advanced devices such as robotic gloves and interactive therapy systems, delivered three times a week for 12 to 15 one-hour sessions. This technology-based treatment is provided alongside standard therapies like physiotherapy and occupational therapy. The study is a single-cohort design with assessments before and after the 4 to 5 week intervention period. Participants will undergo clinical evaluations measuring upper limb motor function using tools like the Fugl-Meyer Assessment and the Action Research Arm Test, along with instrumental tests of active range of motion and grip strength. Physiotherapists will track treatment details in diaries including session numbers and device usage. The study assesses changes over the treatment period and examines relationships between therapy dosage and motor improvements, with safety and clinical relevance carefully monitored.

Researchers are evaluating the effectiveness of the Gloreha Sinfonia4 robotic exoskeleton for upper limb rehabilitation in people who have experienced subacute post-stroke paresis. This international multicenter randomized controlled trial aims to compare robotic-assisted therapy combined with conventional rehabilitation against conventional therapy alone. The main goal is to see if robotic therapy improves voluntary motor control and coordination better, measured by the Fugl-Meyer Assessment for the upper limb motor function. Secondary goals include assessing muscle strength, range of motion, coordination, manual skill, independence in daily activities, patient satisfaction, and any adverse events. Participants are randomly assigned to one of two groups the Experimental Group EG receives robotic-assisted upper limb rehabilitation along with conventional physical and occupational therapy, while the Control Group CG receives only conventional therapy. Both groups undergo 18 sessions, 3 to 5 times per week, with each daily session lasting 90 minutes. The robotic therapy in the EG progresses through passive, assisted, and active mobilization modes over five weeks, with personalized adjustments based on motor ability. Conventional therapy includes tailored motor exercises for shoulder, elbow, wrist, and hand. The study includes a recruitment and treatment phase followed by a 3-month follow-up period. Participants will have clinical assessments at baseline, after treatment around 35 days, and at 3 months follow-up around 125 days. Evaluations include motor function scales, muscle strength, spasticity, pain, dexterity tests, independence measures, and patient satisfaction questionnaires. Follow-up assessments may be conducted in person or by phone using remote scales. Data collection is anonymized and securely stored. Researchers will analyze the clinical and demographic data to understand treatment effects, patient response factors, and rehabilitation outcomes over the 36-month study duration.