Francavilla Fontana

Researchers are evaluating the effects of a combination of natural supplements—Epigallocatechin gallate, Vitamin D, D-chiro-inositol, and Vitamin B6—on the size of uterine fibroids in women. This study aims to understand how these supplements impact fibroid volume, especially in women who have fibroids with a diameter of 4 cm or more, or multiple fibroids, and who experience symptoms like heavy menstrual bleeding or pelvic pain. Participants will be divided into two groups, with one group receiving the supplement combination and the other receiving a placebo. Those in the treatment group will take two tablets daily for three months, each tablet containing 150 mg of Epigallocatechin gallate, 25 mg of D-chiro-inositol, 5 mg of Vitamin B6, and 25 mcg of Vitamin D. The placebo group will receive maltodextrin tablets. The study compares the effects of these tablets over a three-month treatment period. Women in the study will be assessed at the beginning and at the end of the three-month period to measure the change in fibroid diameter. Researchers will monitor symptoms and measure fibroid size to evaluate the impact of the treatment. The study specifically includes women aged 30 to 40 years who are candidates for surgery and excludes those with high body mass index, pregnancy, breastfeeding, diabetes, or cancer diagnoses.