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Researchers are studying acute intoxications in children to better understand how often these poisonings occur and what social and care factors contribute to them. This research focuses on children from 1 month to 16 years old who experience acute intoxication, aiming to improve future national diagnostic and treatment approaches. The study is a prospective, multicenter observational cohort conducted by AMIETOX at Poison Control Centres and paediatric emergency rooms. The study observes children who come to emergency rooms or contact Poison Control Centres due to acute intoxication, defined as exposure to harmful substances either by toxic nature or improper use. It does not involve specific treatments or interventions but records data over approximately one year to assess incidence and prevalence. This observational approach allows researchers to collect real-world information about poisoning cases in paediatric settings. Participants will be monitored through their visits or calls to study centers, with data collected on the nature and circumstances of the intoxications. Researchers will measure how often these poisonings occur and how widespread they are among children in the study. The study involves no active treatment or placebo, focusing instead on gathering information to inform better care strategies. Participation lasts about one year, during which safety and outcomes are tracked through standard care processes.

Researchers are investigating the impact of the timing of minimally invasive surgery after neoadjuvant chemoradiotherapy for rectal cancer. This multicenter, randomized controlled trial aims to determine whether delaying surgery from the standard 8 weeks to 12 weeks influences the pathological complete response pCR, disease-free survival DFS, and overall survival OS in patients with locally advanced rectal cancer. The trial also explores the quality of life QoL outcomes related to these treatment intervals. Participants are randomly assigned to one of two groups one undergoes minimally invasive surgery, including robotic-assisted or standard laparoscopic procedures, 8 weeks after chemoradiation, and the other 12 weeks after. The trial includes surgeries such as low anterior resection, intersphincteric resection, or abdominoperineal resection using various robotic systems or standard laparoscopic methods. The study involves a recruitment period of 5 years with follow-up continuing for 5 years after the last patient is randomized. During the study, patients will complete questionnaires and undergo preoperative assessments including CT-scan and MRI to confirm tumor staging. Researchers will monitor outcomes including pathological response, survival rates, and quality of life. Patients provide informed consent and are evaluated for eligibility before randomization, which occurs near the start of neoadjuvant treatment. Safety and treatment effects are tracked throughout the study period, which may last up to 10 years including follow-up.